Reference - Detail
RRC ID | 21187 |
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Author | Hibayashi R, Imamura N. |
Title | Action mechanism of a selective anti-cyanobacterial compound, argimicin A. |
Journal | J Antibiot (Tokyo) |
Abstract |
Argimicin A is a potent anti-cyanobacterial compound produced by one of algae-lysing bacteria, Sphingomonas sp. M-17. Since the compound seemed to exhibit selective activities against cyanobacteria and such selectivity were considered to be quite rare, the mode of action of argimicin A was investigated. Argimicin A showed a unique delayed action, i.e., the cyanobacterial cell division continued until at least 36 hours treatment even though the decrement of oxygen evolution has been observed at 24 hours treatment. The compound is concluded to be a photosynthetic inhibitor which interrupts electron transport chain prior to photosystem II. From the preliminary fluorescent spectrum of argimicin A treated cyanobacterial cells, the site of action was speculated to be photo energy transfer from a cyanobacterial specific complex of accessory protein pigments, phycobilisome, to photosystem II. |
Volume | 56(2) |
Pages | 154-9 |
Published | 2003-2-1 |
DOI | 10.7164/antibiotics.56.154 |
PMID | 12715875 |
MeSH | Animals Anti-Bacterial Agents / pharmacology* Cyanobacteria / drug effects* Cyanobacteria / growth & development Cyanobacteria / metabolism Electron Transport Kinetics Light-Harvesting Protein Complexes Microscopy, Fluorescence Oxygen / metabolism Peptides* Photosynthetic Reaction Center Complex Proteins / metabolism Photosystem II Protein Complex Phycobilisomes Proteins / metabolism |
IF | 2.668 |
Times Cited | 4 |
WOS Category | BIOTECHNOLOGY & APPLIED MICROBIOLOGY PHARMACOLOGY & PHARMACY IMMUNOLOGY MICROBIOLOGY |
Resource | |
Algae | NIES-81 NIES-41 NIES-45 NIES-230 NIES-592 NIES-204 NIES-102 NIES-298 |