論文 - 詳細
| RRC ID | 21394 |
|---|---|
| 著者 | Ishizuka A, Tomizuka K, Aoki R, Nishijima T, Saito Y, Inoue R, Ushida K, Mawatari T, Ikeda T. |
| タイトル | Effects of administration of Bifidobacterium animalis subsp. lactis GCL2505 on defecation frequency and bifidobacterial microbiota composition in humans. |
| ジャーナル | J Biosci Bioeng |
| Abstract |
The aim of this study was to evaluate the changes in endogenous bifidobacteria and administered Bifidobacterium animalis subsp. lactis (B. lactis) GCL2505 (GCL2505) in the intestine after administration of GCL2505 by means of a randomized, placebo-controlled double-blind, cross-over study. An increase in the number of total bifidobacteria (the sum of B. bifidum, B. breve, B. longum subsp. longum, B. adolescentis, B. anglatum, B. catenulatum, B. pseudocatenulatum, B. dentium, B. longum subsp. infantis and B. lactis) in the feces were observed after administration of GCL2505 using species- and subspecies-specific real-time polymerase chain reaction analysis. However, the number of endogenous bifidobacteria species (excluding B. lactis) remained unchanged. B. lactis also became the predominant bifidobacterial species. Taking into account the number of GCL2505 administered, the findings further suggested that GCL2505 proliferated in the intestine. In addition, the defecation frequency increased during GCL2505 administration compared with the placebo. Moreover, a single administration study (n=17) clearly demonstrated that GCL2505 successfully reached the intestine before proliferating at least 10-fold. This is the first report to show an increase in intestinal bifidobacteria, with no changes to the endogenous species, and improvements in constipation following proliferation of administered bifidobacteria. |
| 巻・号 | 113(5) |
| ページ | 587-91 |
| 公開日 | 2012-5-1 |
| DOI | 10.1016/j.jbiosc.2011.12.016 |
| PII | S1389-1723(11)00534-2 |
| PMID | 22284965 |
| MeSH | Adult Bifidobacterium / genetics Bifidobacterium / growth & development Bifidobacterium / physiology* Biodiversity Colony Count, Microbial Constipation / microbiology Cross-Over Studies Defecation* Double-Blind Method Feces / microbiology* Female Humans Intestines / microbiology Male Metagenome / genetics Metagenome / physiology* RNA, Ribosomal, 16S / genetics Real-Time Polymerase Chain Reaction Young Adult |
| IF | 2.366 |
| 引用数 | 28 |
| WOS 分野 | FOOD SCIENCE & TECHNOLOGY BIOTECHNOLOGY & APPLIED MICROBIOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 2 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 一般微生物 | JCM 1192 JCM 1194 JCM 1195 JCM 1217 JCM 1222 JCM 1255 JCM 1275 JCM 1649 JCM 7096 |