Reference - Detail
| RRC ID | 21816 |
|---|---|
| Author | Karpowicz P, Zhang Y, Hogenesch JB, Emery P, Perrimon N. |
| Title | The circadian clock gates the intestinal stem cell regenerative state. |
| Journal | Cell Rep |
| Abstract |
The intestine has evolved under constant environmental stresses, because an animal may ingest harmful pathogens or chemicals at any time during its lifespan. Following damage, intestinal stem cells (ISCs) regenerate the intestine by proliferating to replace dying cells. ISCs from diverse animals are remarkably similar, and the Wnt, Notch, and Hippo signaling pathways, important regulators of mammalian ISCs, are conserved from flies to humans. Unexpectedly, we identified the transcription factor period, a component of the circadian clock, to be critical for regeneration, which itself follows a circadian rhythm. We discovered hundreds of transcripts that are regulated by the clock during intestinal regeneration, including components of stress response and regeneration pathways. Disruption of clock components leads to arrhythmic ISC divisions, revealing their underappreciated role in the healing process. |
| Volume | 3(4) |
| Pages | 996-1004 |
| Published | 2013-4-25 |
| DOI | 10.1016/j.celrep.2013.03.016 |
| PII | S2211-1247(13)00123-X |
| PMID | 23583176 |
| PMC | PMC3982394 |
| MeSH | Animals Circadian Clocks* Circadian Rhythm Drosophila / metabolism Drosophila Proteins / genetics Drosophila Proteins / metabolism* Interphase Intestines / cytology Intestines / physiology Period Circadian Proteins / genetics Period Circadian Proteins / metabolism* Regeneration Signal Transduction Stem Cells / cytology* Stem Cells / metabolism Transcription, Genetic |
| IF | 8.109 |
| Times Cited | 61 |
| WOS Category | CELL BIOLOGY |
| Altmetric score |
オルトメトリクス指標項目
|
| The most frequently cited source | X(Twitter) |
| Total number of mentions | 17 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| Drosophila | 8727R-1 |