| RRC ID |
21834
|
| Author |
Nelson B, Freisinger T, Ishii K, Okado K, Shinzawa N, Fukumoto S, Kanuka H.
|
| Title |
Activation of Imd pathway in hemocyte confers infection resistance through humoral response in Drosophila.
|
| Journal |
Biochem Biophys Res Commun
|
| Abstract |
Upon microbial invasion the innate immune system of Drosophila melanogaster mounts a response that comes in two distinct but complimentary forms, humoral and cellular. A screen to find genes capable of conferring resistance to the Gram-positive Staphylococcus aureus upon ectopic expression in immune response tissues uncovered imd gene. This resistance was not dependent on cellular defenses but rather likely a result of upregulation of the humoral response through increased expression of antimicrobial peptides, including a Toll pathway reporter gene drosomycin. Taken together it appears that Imd pathway is capable of playing a role in resistance to the Gram-positive S. aureus, counter to notions of traditional roles of the Imd pathway thought largely to responsible for resistance to Gram-negative bacteria.
|
| Volume |
430(3)
|
| Pages |
1120-5
|
| Published |
2013-1-18
|
| DOI |
10.1016/j.bbrc.2012.12.027
|
| PII |
S0006-291X(12)02356-X
|
| PMID |
23261474
|
| MeSH |
Animals
Drosophila Proteins / genetics
Drosophila Proteins / metabolism*
Drosophila melanogaster / immunology*
Drosophila melanogaster / microbiology*
Hemocytes / immunology*
Immunity, Humoral / genetics
Immunity, Humoral / immunology*
Signal Transduction
Staphylococcus aureus / immunology*
|
| IF |
2.985
|
| Times Cited |
1
|
|
WOS Category
|
BIOPHYSICS
BIOCHEMISTRY & MOLECULAR BIOLOGY
|
| Resource |
| Drosophila |
10520R-1
5576R-1
4909R-1
1388R-1
16910R-4
12297R-1 |
