論文 - 詳細
| RRC ID | 21842 |
|---|---|
| 著者 | VoSSfeldt H, Butzlaff M, PrüSSing K, Ní Chárthaigh RA, Karsten P, Lankes A, Hamm S, Simons M, Adryan B, Schulz JB, Voigt A. |
| タイトル | Large-scale screen for modifiers of ataxin-3-derived polyglutamine-induced toxicity in Drosophila. |
| ジャーナル | PLoS One |
| Abstract |
Polyglutamine (polyQ) diseases represent a neuropathologically heterogeneous group of disorders. The common theme of these disorders is an elongated polyQ tract in otherwise unrelated proteins. So far, only symptomatic treatment can be applied to patients suffering from polyQ diseases. Despite extensive research, the molecular mechanisms underlying polyQ-induced toxicity are largely unknown. To gain insight into polyQ pathology, we performed a large-scale RNAi screen in Drosophila to identify modifiers of toxicity induced by expression of truncated Ataxin-3 containing a disease-causing polyQ expansion. We identified various unknown modifiers of polyQ toxicity. Large-scale analysis indicated a dissociation of polyQ aggregation and toxicity. |
| 巻・号 | 7(11) |
| ページ | e47452 |
| 公開日 | 2012-11-5 |
| DOI | 10.1371/journal.pone.0047452 |
| PII | PONE-D-12-03063 |
| PMID | 23139745 |
| PMC | PMC3489908 |
| MeSH | Animals Ataxin-3 Computational Biology Drosophila Proteins / chemistry Drosophila Proteins / metabolism* Drosophila melanogaster / drug effects* Drosophila melanogaster / metabolism* Models, Biological Nerve Tissue Proteins / chemistry Nerve Tissue Proteins / metabolism* Nuclear Proteins / chemistry Nuclear Proteins / metabolism* Peptides / chemistry Peptides / toxicity* Protein Structure, Quaternary RNA Interference* Repressor Proteins / chemistry Repressor Proteins / metabolism* Retina / drug effects Retina / pathology |
| IF | 2.74 |
| 引用数 | 14 |
| WOS 分野 | BIOCHEMISTRY & MOLECULAR BIOLOGY |
| リソース情報 | |
| ショウジョウバエ | |