論文 - 詳細
| RRC ID | 21924 |
|---|---|
| 著者 | Sieber MH, Thummel CS. |
| タイトル | The DHR96 nuclear receptor controls triacylglycerol homeostasis in Drosophila. |
| ジャーナル | Cell Metab |
| Abstract |
Triacylglycerol (TAG) homeostasis is an integral part of normal physiology and essential for proper energy metabolism. Here we show that the single Drosophila ortholog of the PXR and CAR nuclear receptors, DHR96, plays an essential role in TAG homeostasis. DHR96 mutants are sensitive to starvation, have reduced levels of TAG in the fat body and midgut, and are resistant to diet-induced obesity, while DHR96 overexpression leads to starvation resistance and increased TAG levels. We show that DHR96 function is required in the midgut for the breakdown of dietary fat and that it exerts this effect through the CG5932 gastric lipase, which is essential for TAG homeostasis. This study provides insights into the regulation of dietary fat metabolism in Drosophila and demonstrates that the regulation of lipid metabolism is an ancestral function of the PXR/CAR/DHR96 nuclear receptor subfamily. |
| 巻・号 | 10(6) |
| ページ | 481-90 |
| 公開日 | 2009-12-1 |
| DOI | 10.1016/j.cmet.2009.10.010 |
| PII | S1550-4131(09)00336-2 |
| PMID | 19945405 |
| PMC | PMC2803078 |
| MeSH | Animals Drosophila Drosophila Proteins / genetics* Drosophila Proteins / metabolism* Fat Body / metabolism Homeostasis Lipase / metabolism* Lipid Metabolism Male Receptors, Cytoplasmic and Nuclear / genetics* Receptors, Cytoplasmic and Nuclear / metabolism* Starvation Triglycerides / metabolism* |
| IF | 21.567 |
| 引用数 | 81 |
| WOS 分野 | ENDOCRINOLOGY & METABOLISM CELL BIOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 2 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ショウジョウバエ | 5932R-3 |