論文 - 詳細
| RRC ID | 21974 |
|---|---|
| 著者 | Denton D, Chang TK, Nicolson S, Shravage B, Simin R, Baehrecke EH, Kumar S. |
| タイトル | Relationship between growth arrest and autophagy in midgut programmed cell death in Drosophila. |
| ジャーナル | Cell Death Differ |
| Abstract |
Autophagy has been implicated in both cell survival and programmed cell death (PCD), and this may explain the apparently complex role of this catabolic process in tumourigenesis. Our previous studies have shown that caspases have little influence on Drosophila larval midgut PCD, whereas inhibition of autophagy severely delays midgut removal. To assess upstream signals that regulate autophagy and larval midgut degradation, we have examined the requirement of growth signalling pathways. Inhibition of the class I phosphoinositide-3-kinase (PI3K) pathway prevents midgut growth, whereas ectopic PI3K and Ras signalling results in larger cells with decreased autophagy and delayed midgut degradation. Furthermore, premature induction of autophagy is sufficient to induce early midgut degradation. These data indicate that autophagy and the growth regulatory pathways have an important relationship during midgut PCD. Despite the roles of autophagy in both survival and death, our findings suggest that autophagy induction occurs in response to similar signals in both scenarios. |
| 巻・号 | 19(8) |
| ページ | 1299-307 |
| 公開日 | 2012-8-1 |
| DOI | 10.1038/cdd.2012.43 |
| PII | cdd201243 |
| PMID | 22555456 |
| PMC | PMC3392632 |
| MeSH | Animals Apoptosis / physiology Autophagy / physiology* Cell Growth Processes / physiology Cell Survival / physiology Digestive System / cytology Digestive System / metabolism Drosophila / cytology* Drosophila / physiology Immunohistochemistry |
| IF | 10.717 |
| 引用数 | 42 |
| WOS 分野 | BIOCHEMISTRY & MOLECULAR BIOLOGY CELL BIOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 各媒体での言及数の合計 | 0 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ショウジョウバエ | NP1 (DGRC#112001) |