RRC ID 21974
著者 Denton D, Chang TK, Nicolson S, Shravage B, Simin R, Baehrecke EH, Kumar S.
タイトル Relationship between growth arrest and autophagy in midgut programmed cell death in Drosophila.
ジャーナル Cell Death Differ
Abstract Autophagy has been implicated in both cell survival and programmed cell death (PCD), and this may explain the apparently complex role of this catabolic process in tumourigenesis. Our previous studies have shown that caspases have little influence on Drosophila larval midgut PCD, whereas inhibition of autophagy severely delays midgut removal. To assess upstream signals that regulate autophagy and larval midgut degradation, we have examined the requirement of growth signalling pathways. Inhibition of the class I phosphoinositide-3-kinase (PI3K) pathway prevents midgut growth, whereas ectopic PI3K and Ras signalling results in larger cells with decreased autophagy and delayed midgut degradation. Furthermore, premature induction of autophagy is sufficient to induce early midgut degradation. These data indicate that autophagy and the growth regulatory pathways have an important relationship during midgut PCD. Despite the roles of autophagy in both survival and death, our findings suggest that autophagy induction occurs in response to similar signals in both scenarios.
巻・号 19(8)
ページ 1299-307
公開日 2012-8-1
DOI 10.1038/cdd.2012.43
PII cdd201243
PMID 22555456
PMC PMC3392632
MeSH Animals Apoptosis / physiology Autophagy / physiology* Cell Growth Processes / physiology Cell Survival / physiology Digestive System / cytology Digestive System / metabolism Drosophila / cytology* Drosophila / physiology Immunohistochemistry
IF 10.717
引用数 42
WOS 分野 BIOCHEMISTRY & MOLECULAR BIOLOGY CELL BIOLOGY
リソース情報
ショウジョウバエ NP1 (DGRC#112001)