論文 - 詳細
| RRC ID | 21976 |
|---|---|
| 著者 | Sannang RT, Robertson H, Siddall NA, Hime GR. |
| タイトル | Akap200 suppresses the effects of Dv-cbl expression in the Drosophila eye. |
| ジャーナル | Mol Cell Biochem |
| Abstract |
The Drosophila melanogaster orthologue of the c-Cbl proto-oncogene acts to downregulate signalling from receptor tyrosine kinases by enhancing endocytosis of activated receptors. Expression of an analogue of the C-terminally truncated v-Cbl oncogene, Dv-cbl, in the developing Drosophila eye conversely leads to excess signalling and disruption to the well-ordered adult compound eye. Co-expression of activated Ras with Dv-cbl leads to a severe disruption of eye development. We have used a transposon-based inducible expression system to screen for molecules that can suppress the Dv-cbl phenotype and have identified an allele that upregulates the A-kinase anchoring protein, Akap200. Overexpression of Akap200 not only suppresses the phenotype caused by Dv-cbl expression, but also the severe disruption to eye development caused by the combined expression of Dv-cbl and activated Ras. Akap200 is also endogenously expressed in the developing Drosophila eye at a level that modulates the effects of excessive signalling caused by expression of Dv-cbl. |
| 巻・号 | 369(1-2) |
| ページ | 135-45 |
| 公開日 | 2012-10-1 |
| DOI | 10.1007/s11010-012-1376-x |
| PMID | 22773306 |
| MeSH | A Kinase Anchor Proteins* / genetics A Kinase Anchor Proteins* / metabolism Animals Drosophila Proteins* / genetics Drosophila Proteins* / metabolism Drosophila melanogaster Eye / growth & development* Eye / metabolism Gene Expression Regulation, Developmental Membrane Proteins* / genetics Membrane Proteins* / metabolism Proto-Oncogene Proteins c-cbl* / genetics Proto-Oncogene Proteins c-cbl* / metabolism Signal Transduction ras Proteins* / genetics ras Proteins* / metabolism |
| IF | 2.795 |
| 引用数 | 1 |
| WOS 分野 | CELL BIOLOGY |
| リソース情報 | |
| ショウジョウバエ | GS2208 ほか |