RRC ID |
220
|
著者 |
Kondo M, Nanda I, Hornung U, Asakawa S, Shimizu N, Mitani H, Schmid M, Shima A, Schartl M.
|
タイトル |
Absence of the candidate male sex-determining gene dmrt1b(Y) of medaka from other fish species.
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ジャーナル |
Curr Biol
|
Abstract |
Although the sex-determining genes are known in mammals, Drosophila, and C. elegans, little is known in other animals. Fishes are an attractive group of organisms for studying the evolution of sex determination because they show an amazing variety of mechanisms, ranging from environmental sex determination and different forms of hermaphroditism to classical sex chromosomal XX/XY or WZ/ZZ systems and modifications thereof. In the fish medaka, dmrt1b(Y) has recently been found to be the candidate male sex-determining gene. It is a duplicate of the autosomal dmrt1a gene, a gene acting in the sex determination/differentiation cascade of flies, worms, and mammals. Because in birds dmrt1 is located on the Z-chromosome, both findings led to the suggestion that dmrt1b(Y) is a "non-mammalian Sry" with an even more widespread distribution. However, although Sry was found to be the male sex-determining gene in the mouse and some other mammalian species, in some it is absent and has obviously been replaced by other genes that now fulfil the same function. We have asked if the same might be true of the dmrt1b(Y) gene. We find that the gene duplication generating dmrt1b(Y) occurred recently during the evolution of the genus Oryzias. The gene is absent from all other fish species studied. Therefore, it may not be the male-sex determining gene in all fishes.
|
巻・号 |
13(5)
|
ページ |
416-20
|
公開日 |
2003-3-4
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DOI |
10.1016/s0960-9822(03)00125-8
|
PII |
S0960-9822(03)00125-8
|
PMID |
12620191
|
MeSH |
Amino Acid Sequence
Animals
Blotting, Southern
Male
Molecular Sequence Data
Oryzias / genetics*
Oryzias / metabolism
Phylogeny
Sequence Alignment
Sex Determination Processes*
Transcription Factors / genetics*
Transcription Factors / metabolism
Y Chromosome*
|
IF |
9.601
|
引用数 |
109
|
WOS 分野
|
BIOCHEMISTRY & MOLECULAR BIOLOGY
CELL BIOLOGY
|
リソース情報 |
メダカ |
HB32C (IB964)
SOK
O. mekongensis
O. celebensis
HNI
Carbio (Cab) |