Reference - Detail
| RRC ID | 22007 |
|---|---|
| Author | Arif S, Murat S, Almudi I, Nunes MD, Bortolamiol-Becet D, McGregor NS, Currie JM, Hughes H, Ronshaugen M, Sucena É, Lai EC, Schlötterer C, McGregor AP. |
| Title | Evolution of mir-92a underlies natural morphological variation in Drosophila melanogaster. |
| Journal | Curr Biol |
| Abstract |
Identifying the genetic mechanisms underlying phenotypic change is essential to understanding how gene regulatory networks and ultimately the genotype-to-phenotype map evolve. It is recognized that microRNAs (miRNAs) have the potential to facilitate evolutionary change [1-3]; however, there are no known examples of natural morphological variation caused by evolutionary changes in miRNA expression. Therefore, the contribution of miRNAs to evolutionary change remains unknown [1, 4]. Drosophila melanogaster subgroup species display a portion of trichome-free cuticle on the femur of the second leg called the "naked valley." It was previously shown that Ultrabithorax (Ubx) is involved in naked valley variation between D. melanogaster and D. simulans [5, 6]. However, naked valley size also varies among populations of D. melanogaster, ranging from 1,000 up to 30,000 μm(2). We investigated the genetic basis of intraspecific differences in the naked valley in D. melanogaster and found that neither Ubx nor shavenbaby (svb) [7, 8] contributes to this morphological difference. Instead, we show that changes in mir-92a expression underlie the evolution of naked valley size in D. melanogaster through repression of shavenoid (sha) [9]. Therefore, our results reveal a novel mechanism for morphological evolution and suggest that modulation of the expression of miRNAs potentially plays a prominent role in generating organismal diversity. |
| Volume | 23(6) |
| Pages | 523-8 |
| Published | 2013-3-18 |
| DOI | 10.1016/j.cub.2013.02.018 |
| PII | S0960-9822(13)00189-9 |
| PMID | 23453955 |
| PMC | PMC3605577 |
| MeSH | Animals Chromosome Mapping Drosophila melanogaster / anatomy & histology* Drosophila melanogaster / genetics* Drosophila melanogaster / growth & development Drosophila melanogaster / metabolism Evolution, Molecular* Extremities / anatomy & histology Female Gene Expression Regulation, Developmental* In Situ Hybridization Male MicroRNAs / genetics* MicroRNAs / metabolism Pupa / anatomy & histology Pupa / genetics Pupa / growth & development Pupa / metabolism Quantitative Trait Loci |
| IF | 9.601 |
| Times Cited | 24 |
| WOS Category | BIOCHEMISTRY & MOLECULAR BIOLOGY CELL BIOLOGY |
| Altmetric score |
オルトメトリクス指標項目
|
| The most frequently cited source | X(Twitter) |
| Total number of mentions | 9 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| Drosophila | st ss e (DGRC#101760) |