RRC ID 22019
著者 Singh AP, Das RN, Rao G, Aggarwal A, Diegelmann S, Evers JF, Karandikar H, Landgraf M, Rodrigues V, Vijayraghavan K.
タイトル Sensory neuron-derived eph regulates glomerular arbors and modulatory function of a central serotonergic neuron.
ジャーナル PLoS Genet
Abstract Olfactory sensory neurons connect to the antennal lobe of the fly to create the primary units for processing odor cues, the glomeruli. Unique amongst antennal-lobe neurons is an identified wide-field serotonergic neuron, the contralaterally-projecting, serotonin-immunoreactive deutocerebral neuron (CSDn). The CSDn spreads its termini all over the contralateral antennal lobe, suggesting a diffuse neuromodulatory role. A closer examination, however, reveals a restricted pattern of the CSDn arborization in some glomeruli. We show that sensory neuron-derived Eph interacts with Ephrin in the CSDn, to regulate these arborizations. Behavioural analysis of animals with altered Eph-ephrin signaling and with consequent arborization defects suggests that neuromodulation requires local glomerular-specific patterning of the CSDn termini. Our results show the importance of developmental regulation of terminal arborization of even the diffuse modulatory neurons to allow them to route sensory-inputs according to the behavioural contexts.
巻・号 9(4)
ページ e1003452
公開日 2013-4-1
DOI 10.1371/journal.pgen.1003452
PII PGENETICS-D-13-00078
PMID 23637622
PMC PMC3630106
MeSH Animals Odorants Olfactory Pathways Olfactory Receptor Neurons* Sensory Receptor Cells Serotonergic Neurons* Serotonin
IF 5.175
引用数 15
WOS 分野 GENETICS & HEREDITY
リソース情報
ショウジョウバエ wg[1-16]