論文 - 詳細
| RRC ID | 22019 |
|---|---|
| 著者 | Singh AP, Das RN, Rao G, Aggarwal A, Diegelmann S, Evers JF, Karandikar H, Landgraf M, Rodrigues V, Vijayraghavan K. |
| タイトル | Sensory neuron-derived eph regulates glomerular arbors and modulatory function of a central serotonergic neuron. |
| ジャーナル | PLoS Genet |
| Abstract |
Olfactory sensory neurons connect to the antennal lobe of the fly to create the primary units for processing odor cues, the glomeruli. Unique amongst antennal-lobe neurons is an identified wide-field serotonergic neuron, the contralaterally-projecting, serotonin-immunoreactive deutocerebral neuron (CSDn). The CSDn spreads its termini all over the contralateral antennal lobe, suggesting a diffuse neuromodulatory role. A closer examination, however, reveals a restricted pattern of the CSDn arborization in some glomeruli. We show that sensory neuron-derived Eph interacts with Ephrin in the CSDn, to regulate these arborizations. Behavioural analysis of animals with altered Eph-ephrin signaling and with consequent arborization defects suggests that neuromodulation requires local glomerular-specific patterning of the CSDn termini. Our results show the importance of developmental regulation of terminal arborization of even the diffuse modulatory neurons to allow them to route sensory-inputs according to the behavioural contexts. |
| 巻・号 | 9(4) |
| ページ | e1003452 |
| 公開日 | 2013-4-1 |
| DOI | 10.1371/journal.pgen.1003452 |
| PII | PGENETICS-D-13-00078 |
| PMID | 23637622 |
| PMC | PMC3630106 |
| MeSH | Animals Odorants Olfactory Pathways Olfactory Receptor Neurons* Sensory Receptor Cells Serotonergic Neurons* Serotonin |
| IF | 5.175 |
| 引用数 | 15 |
| WOS 分野 | GENETICS & HEREDITY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
|
| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 5 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ショウジョウバエ | wg[1-16] |