| RRC ID |
22019
|
| 著者 |
Singh AP, Das RN, Rao G, Aggarwal A, Diegelmann S, Evers JF, Karandikar H, Landgraf M, Rodrigues V, Vijayraghavan K.
|
| タイトル |
Sensory neuron-derived eph regulates glomerular arbors and modulatory function of a central serotonergic neuron.
|
| ジャーナル |
PLoS Genet
|
| Abstract |
Olfactory sensory neurons connect to the antennal lobe of the fly to create the primary units for processing odor cues, the glomeruli. Unique amongst antennal-lobe neurons is an identified wide-field serotonergic neuron, the contralaterally-projecting, serotonin-immunoreactive deutocerebral neuron (CSDn). The CSDn spreads its termini all over the contralateral antennal lobe, suggesting a diffuse neuromodulatory role. A closer examination, however, reveals a restricted pattern of the CSDn arborization in some glomeruli. We show that sensory neuron-derived Eph interacts with Ephrin in the CSDn, to regulate these arborizations. Behavioural analysis of animals with altered Eph-ephrin signaling and with consequent arborization defects suggests that neuromodulation requires local glomerular-specific patterning of the CSDn termini. Our results show the importance of developmental regulation of terminal arborization of even the diffuse modulatory neurons to allow them to route sensory-inputs according to the behavioural contexts.
|
| 巻・号 |
9(4)
|
| ページ |
e1003452
|
| 公開日 |
2013-4-1
|
| DOI |
10.1371/journal.pgen.1003452
|
| PII |
PGENETICS-D-13-00078
|
| PMID |
23637622
|
| PMC |
PMC3630106
|
| MeSH |
Animals
Odorants
Olfactory Pathways
Olfactory Receptor Neurons*
Sensory Receptor Cells
Serotonergic Neurons*
Serotonin
|
| IF |
5.175
|
| 引用数 |
15
|
|
WOS 分野
|
GENETICS & HEREDITY
|
| リソース情報 |
| ショウジョウバエ |
wg[1-16] |
