論文 - 詳細
| RRC ID | 22755 |
|---|---|
| 著者 | Katsuma S, Koyano Y, Kang W, Kokusho R, Kamita SG, Shimada T. |
| タイトル | The baculovirus uses a captured host phosphatase to induce enhanced locomotory activity in host caterpillars. |
| ジャーナル | PLoS Pathog |
| Abstract |
The baculovirus is a classic example of a parasite that alters the behavior or physiology of its host so that progeny transmission is maximized. Baculoviruses do this by inducing enhanced locomotory activity (ELA) that causes the host caterpillars to climb to the upper foliage of plants. We previously reported that this behavior is not induced in silkworms that are infected with a mutant baculovirus lacking its protein tyrosine phosphatase (ptp) gene, a gene likely captured from an ancestral host. Here we show that the product of the ptp gene, PTP, associates with baculovirus ORF1629 as a virion structural protein, but surprisingly phosphatase activity associated with PTP was not required for the induction of ELA. Interestingly, the ptp knockout baculovirus showed significantly reduced infectivity of larval brain tissues. Collectively, we show that the modern baculovirus uses the host-derived phosphatase to establish adequate infection for ELA as a virion-associated structural protein rather than as an enzyme. |
| 巻・号 | 8(4) |
| ページ | e1002644 |
| 公開日 | 2012-1-1 |
| DOI | 10.1371/journal.ppat.1002644 |
| PII | PPATHOGENS-D-11-02707 |
| PMID | 22496662 |
| PMC | PMC3320614 |
| MeSH | Animals Baculoviridae / enzymology* Baculoviridae / genetics Bombyx / enzymology* Bombyx / genetics Bombyx / virology* Gene Knockdown Techniques Insect Proteins / genetics Insect Proteins / metabolism* Phosphoric Monoester Hydrolases / genetics Phosphoric Monoester Hydrolases / metabolism* Viral Proteins / genetics Viral Proteins / metabolism* |
| IF | 6.218 |
| 引用数 | 44 |
| WOS 分野 | PARASITOLOGY MICROBIOLOGY VIROLOGY |
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