RRC ID 22755
Author Katsuma S, Koyano Y, Kang W, Kokusho R, Kamita SG, Shimada T.
Title The baculovirus uses a captured host phosphatase to induce enhanced locomotory activity in host caterpillars.
Journal PLoS Pathog
Abstract The baculovirus is a classic example of a parasite that alters the behavior or physiology of its host so that progeny transmission is maximized. Baculoviruses do this by inducing enhanced locomotory activity (ELA) that causes the host caterpillars to climb to the upper foliage of plants. We previously reported that this behavior is not induced in silkworms that are infected with a mutant baculovirus lacking its protein tyrosine phosphatase (ptp) gene, a gene likely captured from an ancestral host. Here we show that the product of the ptp gene, PTP, associates with baculovirus ORF1629 as a virion structural protein, but surprisingly phosphatase activity associated with PTP was not required for the induction of ELA. Interestingly, the ptp knockout baculovirus showed significantly reduced infectivity of larval brain tissues. Collectively, we show that the modern baculovirus uses the host-derived phosphatase to establish adequate infection for ELA as a virion-associated structural protein rather than as an enzyme.
Volume 8(4)
Pages e1002644
Published 2012-1-1
DOI 10.1371/journal.ppat.1002644
PMID 22496662
PMC PMC3320614
MeSH Animals Baculoviridae / enzymology* Baculoviridae / genetics Bombyx / enzymology* Bombyx / genetics Bombyx / virology* Gene Knockdown Techniques Insect Proteins / genetics Insect Proteins / metabolism* Phosphoric Monoester Hydrolases / genetics Phosphoric Monoester Hydrolases / metabolism* Viral Proteins / genetics Viral Proteins / metabolism*
IF 6.218
Times Cited 44