論文 - 詳細
| RRC ID | 2276 |
|---|---|
| 著者 | Gründemann C, Bauer M, Schweier O, von Oppen N, Lässing U, Saudan P, Becker KF, Karp K, Hanke T, Bachmann MF, Pircher H. |
| タイトル | Cutting edge: identification of E-cadherin as a ligand for the murine killer cell lectin-like receptor G1. |
| ジャーナル | J Immunol |
| Abstract |
The killer cell lectin-like receptor G1 (KLRG1) is expressed by NK cells and by T cells. In both humans and mice, KLRG1 identifies Ag-experienced T cells that are impaired in their proliferative capacity but are capable of performing effector functions. In this study, we identified E-cadherin as a ligand for murine KLRG1 by using fluorescently labeled, soluble tetrameric complexes of the extracellular domain of the murine KLRG1 molecule as staining reagents in expression cloning. Ectopic expression of E-cadherin in B16.BL6 target cells did not affect cell-mediated lysis by lymphokine-activated NK cells and by CD8 T cells but inhibited Ag-induced proliferation and induction of cytolytic activity of CD8 T cells. E-cadherin is expressed by normal epithelial cells, Langerhans cells, and keratinocytes and is usually down-regulated on metastatic cancer cells. KLRG1 ligation by E-cadherin in healthy tissue may thus exert an inhibitory effect on primed T cells. |
| 巻・号 | 176(3) |
| ページ | 1311-5 |
| 公開日 | 2006-2-1 |
| DOI | 10.4049/jimmunol.176.3.1311 |
| PII | 176/3/1311 |
| PMID | 16424155 |
| MeSH | Animals Antigens / immunology CD8-Positive T-Lymphocytes / cytology CD8-Positive T-Lymphocytes / immunology CD8-Positive T-Lymphocytes / metabolism Cadherins / biosynthesis Cadherins / metabolism* Cadherins / physiology Cell Division / immunology Cell Line Growth Inhibitors / biosynthesis Growth Inhibitors / metabolism Growth Inhibitors / physiology Killer Cells, Lymphokine-Activated / immunology Killer Cells, Lymphokine-Activated / metabolism Lectins, C-Type Ligands Melanoma, Experimental Mice Mice, Inbred C57BL Mice, Transgenic Receptors, Immunologic / genetics Receptors, Immunologic / metabolism* |
| IF | 4.886 |
| 引用数 | 105 |
| WOS 分野 | IMMUNOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
|
| 最多言及媒体 | F1000Research |
| 各媒体での言及数の合計 | 2 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 遺伝子材料 | Mouse E-cadherin full length cDNA (RDB01184) |