| RRC ID |
22811
|
| Author |
Kurokawa K, Hamamoto H, Matsuo M, Nishida S, Yamane N, Lee BL, Murakami K, Maki H, Sekimizu K.
|
| Title |
Evaluation of target specificity of antibacterial agents using Staphylococcus aureus ddlA mutants and D-cycloserine in a silkworm infection model.
|
| Journal |
Antimicrob Agents Chemother
|
| Abstract |
The availability of a silkworm larva infection model to evaluate the therapeutic effectiveness of antibiotics was examined. The 50% effective doses (ED50) of D-cycloserine against the Staphylococcus aureus ddlA mutant-mediated killing of larvae were remarkably lower than those against the parental strain-mediated killing of larvae. Changes in MICs and ED50 of other antibiotics were negligible, suggesting that these alterations are d-cycloserine selective. Therefore, this model is useful for selecting desired compounds based on their therapeutic effectiveness during antibiotic development.
|
| Volume |
53(9)
|
| Pages |
4025-7
|
| Published |
2009-9-1
|
| DOI |
10.1128/AAC.00200-09
|
| PII |
AAC.00200-09
|
| PMID |
19546371
|
| PMC |
PMC2737873
|
| MeSH |
Animals
Anti-Bacterial Agents / pharmacology*
Bombyx / microbiology*
Cephalosporins / pharmacology
Chloramphenicol / pharmacology
Cycloserine / pharmacology*
Inhibitory Concentration 50
Larva / immunology
Microbial Sensitivity Tests
Staphylococcus aureus / drug effects*
Tetracycline / pharmacology
Vancomycin / pharmacology
|
| IF |
4.904
|
| Times Cited |
12
|
|
WOS Category
|
PHARMACOLOGY & PHARMACY
MICROBIOLOGY
|
| Resource |
| Silkworms |
|
