RRC ID 22823
著者 Suzuki T, Sakurai S, Iwami M.
タイトル Steroidal regulation of hydrolyzing activity of the dietary carbohydrates in the silkworm, Bombyx mori.
ジャーナル J Insect Physiol
Abstract Blood sugar is an essential energy source for growth and development and is maintained at a constant level through precise regulation of formation and utilization. Sugars are produced from dietary carbohydrates by enzymatic hydrolysis in the digestive tract, which are under the homeostatic control of paracrine and prandial mechanisms in mammals. Here, we show that dietary carbohydrates hydrolyzing activity of the digestive tract is developmentally regulated by the steroid hormone ecdysone in the silkworm, Bombyx mori. The dietary carbohydrates hydrolyzing activity remained high throughout the last larval period and then decreased to negligible levels until the pupal period. However, dietary carbohydrates digestive activities were constitutively high when the steroidogenic organ, prothoracic glands were ablated. The prothoracic glands produced and released a large amount of ecdysone at the end of the larval period, suggesting that ecdysone is responsible for the decrease in dietary carbohydrates hydrolyzing activity. In fact, ecdysone decreased the activity to negligible levels in silkworms lacking the prothoracic glands. The present results indicate that the dietary carbohydrates hydrolyzing activity is regulated by ecdysone and that an increase in ecdysone titer decreases that activity at the end of the larval period, suggesting that ecdysone is essential for metabolic coordination during development.
巻・号 57(9)
ページ 1282-9
公開日 2011-9-1
DOI 10.1016/j.jinsphys.2011.06.003
PII S0022-1910(11)00173-9
PMID 21708163
MeSH Abdomen Animals Bombyx / genetics Bombyx / growth & development Bombyx / metabolism* Carbohydrate Metabolism* Diffusion Ecdysone / metabolism* Feeding Behavior Gene Expression Regulation Genes, Insect Hemolymph / metabolism Hydrolysis Larva / growth & development Larva / metabolism Receptors, Steroid / metabolism
IF 2.246
引用数 6
WOS 分野 ENTOMOLOGY ZOOLOGY PHYSIOLOGY
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