Reference - Detail
| RRC ID | 2402 |
|---|---|
| Author | Nakatomi M, Morita I, Eto K, Ota MS. |
| Title | Sonic hedgehog signaling is important in tooth root development. |
| Journal | J Dent Res |
| Abstract |
Hertwig's epithelial root sheath (HERS) is important for tooth root formation, but the molecular basis for the signaling of root development remains uncertain. We hypothesized that Sonic hedgehog (Shh) signaling is involved in the HERS function, because it mediates epithelial-mesenchymal interactions during embryonic odontogenesis. We examined the gene expression patterns of Shh signaling in murine developing molar roots. Shh and Patched2 transcripts were identified in the HERS, whereas Patched1, Smoothened, and Gli1 were expressed in the proliferative dental mesenchyme in addition to the HERS. To confirm whether Shh signaling physiologically functions in vivo, we analyzed mesenchymal dysplasia (mes) mice carrying an abnormal C-terminus of the PATCHED1 protein. In the mutant, cell proliferation was repressed around the HERS at 1 wk. Moreover, the molar eruption was disturbed, and all roots were shorter than those in control littermates at 4 wks. These results indicate that Shh signaling is important in tooth root development. Abbreviations used: BrdU, 5-bromo-2'-deoxyuridine; HERS, Hertwig's epithelial root sheath; NFI-C/CTF, nuclear factor Ic/CAAT box transcription factor; PCNA, proliferating cell nuclear antigen; Ptc, patched; Shh, sonic hedgehog; Smo, smoothened. |
| Volume | 85(5) |
| Pages | 427-31 |
| Published | 2006-5-1 |
| DOI | 10.1177/154405910608500506 |
| PII | 85/5/427 |
| PMID | 16632755 |
| MeSH | Animals Cell Proliferation Epithelium Gene Expression Regulation, Developmental Hedgehog Proteins In Situ Hybridization Kruppel-Like Transcription Factors / genetics Kruppel-Like Transcription Factors / physiology Mesoderm / pathology Mice Mice, Inbred C57BL Mice, Mutant Strains Morphogenesis / genetics Odontogenesis / genetics* Patched Receptors Patched-1 Receptor Patched-2 Receptor Receptors, Cell Surface / genetics Receptors, Cell Surface / physiology Signal Transduction Tooth Eruption / genetics Tooth Root / growth & development* Trans-Activators / genetics* Trans-Activators / physiology* Zinc Finger Protein GLI1 |
| IF | 4.914 |
| Times Cited | 111 |
| WOS Category | DENTISTRY, ORAL SURGERY & MEDICINE |
| Altmetric score |
オルトメトリクス指標項目
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| The most frequently cited source | Wikipedia |
| Total number of mentions | 6 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| Mice | RBRC00619 |