| RRC ID |
2539
|
| Author |
Niwa T, Nakao M, Hoshi S, Yamada K, Inagaki K, Nishida M, Nabeshima T.
|
| Title |
Effect of dietary fiber on morphine-induced constipation in rats.
|
| Journal |
Biosci Biotechnol Biochem
|
| Abstract |
Morphine is used to alleviate chronic cancer pain. However, constipation is a major adverse effect that often detracts from the patient's quality of life. In this study, we investigated the effectiveness of dietary fiber on morphine-induced constipation. Rats were fed on a normal diet or one containing either 10% or 20% apple fiber for two weeks before morphine was administered. In the control diet group, the fecal number and dry weight were decreased by treating with morphine in a dose-dependent manner. Moreover, the motility of the small and large intestines was reduced. The fecal number and weight were increased and the colon motility was promoted by dietary fiber, regardless of whether morphine was being administered. The dietary fiber increased the concentration of short-chain fatty acids (SCFAs) in the cecum. These results suggest that dietary fiber has a preventative effect on morphine-induced constipation by increasing SCFAs in the cecum, and thereby promoting colon motility in rats.
|
| Volume |
66(6)
|
| Pages |
1233-40
|
| Published |
2002-6-1
|
| DOI |
10.1271/bbb.66.1233
|
| PMID |
12162543
|
| MeSH |
Animals
Cecum / chemistry
Cecum / drug effects
Constipation / chemically induced*
Constipation / prevention & control*
Dietary Fiber / pharmacology*
Dose-Response Relationship, Drug
Fatty Acids, Volatile / analysis
Feces / chemistry
Gastrointestinal Motility / drug effects
Hydrogen-Ion Concentration
Male
Malus / chemistry
Morphine / administration & dosage
Morphine / adverse effects*
Narcotics / adverse effects
Rats
Rats, Sprague-Dawley
Water / analysis
|
| IF |
1.516
|
| Times Cited |
23
|
|
WOS Category
|
CHEMISTRY, APPLIED
FOOD SCIENCE & TECHNOLOGY
BIOTECHNOLOGY & APPLIED MICROBIOLOGY
BIOCHEMISTRY & MOLECULAR BIOLOGY
|
| Resource |
| Pathogenic microorganisms |
|
