論文 - 詳細
| RRC ID | 2572 |
|---|---|
| 著者 | Nagamune K, Acosta-Serrano A, Uemura H, Brun R, Kunz-Renggli C, Maeda Y, Ferguson MA, Kinoshita T. |
| タイトル | Surface sialic acids taken from the host allow trypanosome survival in tsetse fly vectors. |
| ジャーナル | J Exp Med |
| Abstract |
The African trypanosome Trypanosoma brucei, which causes sleeping sickness in humans and Nagana disease in livestock, is spread via blood-sucking Tsetse flies. In the fly's intestine, the trypanosomes survive digestive and trypanocidal environments, proliferate, and translocate into the salivary gland, where they become infectious to the next mammalian host. Here, we show that for successful survival in Tsetse flies, the trypanosomes use trans-sialidase to transfer sialic acids that they cannot synthesize from host's glycoconjugates to the glycosylphosphatidylinositols (GPIs), which are abundantly expressed on their surface. Trypanosomes lacking sialic acids due to a defective generation of GPI-anchored trans-sialidase could not survive in the intestine, but regained the ability to survive when sialylated by means of soluble trans-sialidase. Thus, surface sialic acids appear to protect the parasites from the digestive and trypanocidal environments in the midgut of Tsetse flies. |
| 巻・号 | 199(10) |
| ページ | 1445-50 |
| 公開日 | 2004-5-17 |
| DOI | 10.1084/jem.20030635 |
| PII | jem.20030635 |
| PMID | 15136592 |
| PMC | PMC2211819 |
| MeSH | Animals Glycoconjugates / antagonists & inhibitors Glycoconjugates / biosynthesis Glycosylphosphatidylinositols / immunology Humans Insect Vectors / parasitology Neuraminidase / immunology* Salivary Glands / parasitology Sialic Acids / analysis* Trypanosoma brucei brucei / growth & development* Trypanosomiasis, African / transmission Tsetse Flies / parasitology* |
| IF | 11.743 |
| 引用数 | 62 |
| WOS 分野 | MEDICINE, RESEARCH & EXPERIMENTAL IMMUNOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
|
| 各媒体での言及数の合計 | 0 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 病原微生物 | T. brucei? |