| RRC ID |
2646
|
| Author |
Hosoe T, Iizuka T, Komai S, Wakana D, Itabashi T, Nozawa K, Fukushima K, Kawai K.
|
| Title |
4-benzyl-3-phenyl-5H-furan-2-one, a vasodilator isolated from Malbranchea filamentosa IFM 41300.
|
| Journal |
Phytochemistry
|
| Abstract |
Screening of Malbranchea filamentosa IFM 41300 for bioactive compounds led to the identification of 4-benzyl-3-phenyl-5H-furan-2-one (1) as a vasodilator and erythroglaucin (2). The structure of 1 was established on the basis of spectroscopic and chemical investigations. Compound 1 inhibited Ca2+-induced vasocintraction in aortic rings pretreated with high K+ (60mM) or norepinephrine. Finally, compound 1 did not exhibit activity against human pathogenic microorganisms.
|
| Volume |
66(23)
|
| Pages |
2776-9
|
| Published |
2005-12-1
|
| DOI |
10.1016/j.phytochem.2005.08.014
|
| PII |
S0031-9422(05)00420-6
|
| PMID |
16213536
|
| MeSH |
Animals
Aorta, Thoracic / drug effects
Aorta, Thoracic / physiology
Benzyl Compounds / chemistry*
Benzyl Compounds / isolation & purification
Benzyl Compounds / pharmacology*
Calcium / pharmacology
Dose-Response Relationship, Drug
Furans / chemistry*
Furans / isolation & purification
Furans / pharmacology*
In Vitro Techniques
Magnetic Resonance Spectroscopy
Male
Microbial Sensitivity Tests
Molecular Structure
Onygenales / chemistry*
Potassium / pharmacology
Rats
Rats, Wistar
Spectrometry, Mass, Electrospray Ionization
Vasodilator Agents / chemistry*
Vasodilator Agents / pharmacology*
|
| IF |
3.044
|
| Times Cited |
18
|
|
WOS Category
|
PLANT SCIENCES
BIOCHEMISTRY & MOLECULAR BIOLOGY
|
| Resource |
| Pathogenic microorganisms |
IFM 40009
IFM 40215
IFM 41243
IFM 41300
IFM 41398 |
