Reference - Detail
| RRC ID | 2650 |
|---|---|
| Author | Ikeda Y, Furumai T, Igarashi Y. |
| Title | Nocardimicins G, H and I, siderophores with muscarinic M3 receptor binding inhibitory activity from Nocardia nova JCM 6044. |
| Journal | J Antibiot (Tokyo) |
| Abstract |
In the screening for muscarinic M3 receptor binding inhibitors from microbial secondary metabolites, the extract of Nocardia nova JCM 6044 was found to be highly active. Bioassay-guided isolation led to the identification of three siderophores, nocardimicins G (1), H (2) and I (3). Their chemical structures were determined by spectroscopic analysis using NMR and MS. 1 and 2 inhibited the binding of tritium-labeled N-methylscopolamine to the muscarinic M3 receptor with Ki values of 0.44 microM and 0.37 microM, respectively, whereas 3 showed no inhibition at 10 microM. 1 and 2 also showed weak binding inhibitory activity to the M5 receptor but not to the M1, M2 and M4 receptors at 10 microM. |
| Volume | 58(9) |
| Pages | 566-72 |
| Published | 2005-9-1 |
| DOI | 10.1038/ja.2005.77 |
| PMID | 16320761 |
| MeSH | Hydroxamic Acids / isolation & purification Hydroxamic Acids / pharmacology Molecular Structure Muscarinic Antagonists / chemistry Muscarinic Antagonists / isolation & purification Muscarinic Antagonists / pharmacokinetics Muscarinic Antagonists / pharmacology Nocardia / chemistry* Oxazoles / isolation & purification Oxazoles / pharmacology Receptor, Muscarinic M3 / antagonists & inhibitors* Receptor, Muscarinic M3 / metabolism Siderophores / chemistry Siderophores / isolation & purification* Siderophores / pharmacology |
| IF | 2.668 |
| Times Cited | 11 |
| WOS Category | PHARMACOLOGY & PHARMACY BIOTECHNOLOGY & APPLIED MICROBIOLOGY IMMUNOLOGY MICROBIOLOGY |
| Resource | |
| Pathogenic microorganisms | JCM 6044 |