論文 - 詳細
| RRC ID | 2688 |
|---|---|
| 著者 | Nakazawa S. |
| タイトル | Plasmodium berghei NK65: studies on the effect of treatment duration and inoculum size on recrudescence. |
| ジャーナル | Exp Parasitol |
| Abstract |
Recrudescence of Plasmodium berghei NK65 infection was studied to examine factors affecting recrudescence. Treatment with a high dose of chloroquine did not prevent recrudescence, but an extended duration of treatment suppressed the frequency of recrudescence. Infection with a larger number of parasites also resulted in more frequent recrudescences. Recrudescent parasites were as sensitive to chloroquine as those before treatment. Splenectomized mice were administered carbon particles, infected, and treated with chloroquine. Recrudescence was significantly more frequent in these mice than in mice given a sham operation and PBS. The results do not suggest that merozoite stages escape the effect of chloroquine by 'hiding' in phagocytes, but that latent parasites such as dormant ring stages may cause recrudescence. |
| 巻・号 | 111(1) |
| ページ | 59-63 |
| 公開日 | 2005-9-1 |
| DOI | 10.1016/j.exppara.2005.05.002 |
| PII | S0014-4894(05)00146-3 |
| PMID | 15961077 |
| MeSH | Animals Antimalarials / administration & dosage Antimalarials / pharmacology Antimalarials / therapeutic use* Chloroquine / administration & dosage Chloroquine / pharmacology Chloroquine / therapeutic use* Dose-Response Relationship, Drug Erythrocytes / parasitology Female Lethal Dose 50 Malaria / drug therapy* Malaria / prevention & control Male Mice Mice, Inbred BALB C Mice, Inbred C57BL Mice, Inbred CBA Mice, Inbred ICR Parasitemia / drug therapy Parasitemia / prevention & control Plasmodium berghei / drug effects Plasmodium berghei / pathogenicity* Secondary Prevention Time Factors |
| IF | 1.69 |
| 引用数 | 3 |
| WOS 分野 | PARASITOLOGY |
| リソース情報 | |
| 病原微生物 | P. berghei NK65? |