論文 - 詳細
| RRC ID | 27731 |
|---|---|
| 著者 | Ohmori I, Hayashi K, Wang H, Ouchida M, Fujita N, Inoue T, Michiue H, Nishiki T, Matsui H. |
| タイトル | Inhalation of 10% carbon dioxide rapidly terminates Scn1a mutation-related hyperthermia-induced seizures. |
| ジャーナル | Epilepsy Res |
| Abstract |
The aim of this study was to assess the anticonvulsant effect of carbon dioxide (CO2) on Scn1a mutation-related febrile seizures. We examined physiological changes in the blood gas levels after the induction of hyperthermia-induced seizures (HISs), which were associated with the Scn1a missense mutation. We determined the efficacy of inhalation of 5% or 10% CO2 to treat HISs. HISs were evoked in Scn1a mutant and wild-type (WT) rats by hot water baths. To determine the anticonvulsant effect of CO2 inhalation, rats were placed in a chamber filled with air or mixed gas containing 5% CO2 or 10% CO2 for 3 min, immediately after the induction of HISs. We also analyzed the blood gas levels at the end of inhalation of CO2. Hot water bathing induced a significant reduction in the partial pressure of CO2 (pCO2) and respiratory alkalosis in the WT and Scn1a mutant rats. HISs were evoked in 100% of the Scn1a mutant rats within 5 min, but in none of the WT rats. The Scn1a mutant rats demonstrated a higher HISs susceptibility associated with respiratory alkalosis than the WT rats. Inhalation of 10% CO2 shortened the seizure duration from 62.6±12.1 s to 15.5±1.0 s. Blood gas analysis after the inhalation of 10% CO2 demonstrated an elevated pCO2 level and respiratory acidosis. Inhalation of 10% CO2 demonstrated a potent and fast-acting anticonvulsant effect against HISs. |
| 巻・号 | 105(1-2) |
| ページ | 220-4 |
| 公開日 | 2013-7-1 |
| DOI | 10.1016/j.eplepsyres.2013.01.003 |
| PII | S0920-1211(13)00016-8 |
| PMID | 23375560 |
| MeSH | Animals Carbon Dioxide / administration & dosage* Fever / drug therapy Fever / genetics* Fever / metabolism Inhalation / physiology Male Mutation, Missense / genetics* NAV1.1 Voltage-Gated Sodium Channel / genetics* Rats Rats, Inbred F344 Rats, Mutant Strains Seizures / drug therapy Seizures / genetics* Seizures / metabolism Time Factors |
| IF | 2.208 |
| 引用数 | 5 |
| WOS 分野 | CLINICAL NEUROLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
|
| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 1 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ラット | F344-Scn1am1Kyo(strainID=716) |