Reference - Detail
|Author||Tachibana M, Lu L, Hiai H, Tamura A, Matsushima Y, Shisa H.|
|Title||Quantitative trait loci determining weight reduction of testes and pituitary by diethylstilbesterol in LEXF and FXLE recombinant inbred strain rats.|
Increasing exposure to environmental endocrine disruptor, xeno-estrogen, is a serious hazard to male reproductive activity. To explore possible genetic control in susceptibility to xeno-estrogen, the weight reduction of testes induced by the continuous administration of a synthetic estrogen, diethylstilbesterol, were investigated by quantitative trait analysis in LEXF and FXLE recombinant inbred strain rats, consisting of 21 independent strains, 9 of their substrains, parental F344/Stm and LE/Stm strains, and (F344 x LE)F1. For the weight of testes, one highly significant quantitative trait locus (QTL) and one significant QTL were mapped on chromosomes 7 and 1, respectively. The QTL on chromosome 7 is closely associated with c-myc. Pituitary weight and serum prolactin were also variable among recombinant inbred strains, but no QTL was detected for them in this study.
|MeSH||Animals Chromosome Mapping Diethylstilbestrol / toxicity* Endocrine Disruptors / toxicity Male Organ Size / drug effects Pituitary Gland / drug effects* Prolactin / blood Rats Rats, Inbred Strains / genetics* Recombination, Genetic Testis / drug effects*|
|WOS Category||VETERINARY SCIENCES ZOOLOGY|
|Rats||LEXF1A/Stm(strainID=219) LEXF1B? LEXF1C/Stm(strainID=221) LEXF2A/Stm(strainID=222) LEXF2B/Stm(strainID=223) LEXF2C/Stm(strainID=224) LEXF3/Stm(strainID=225) LEXF4/Stm(strainID=226) LEXF5/Stm(strainID=227) LEXF7A/Stm(strainID=230) LEXF7B/Stm(strainID=231) LEXF7C/Stm(strainID=232) LEXF8A/Stm(strainID=233) LEXF8D/Stm(strainID=234) LEXF9/Stm(strainID=235) LEXF10A/Stm(strainID=236) LEXF10C/Stm(strainID=238) LEXF11/Stm(strainID=239) FXLE12/Stm(strainID=250) FXLE13/Stm(strainID=251) FXLE17/Stm(strainID=255) FXLE18/Stm(strainID=256) FXLE20/Stm(strainID=258) FXLE22/Stm(strainID=260) FXLE23/Stm(strainID=261) FXLE24/Stm(strainID=262) FXLE25/Stm(strainID=263) FXLE26/Stm(strainID=264) LE/Stm(strainID=265) F344/Stm(strainID=266)|