RRC ID 2795
Author Tachibana M, Lu L, Hiai H, Tamura A, Matsushima Y, Shisa H.
Title Quantitative trait loci determining weight reduction of testes and pituitary by diethylstilbesterol in LEXF and FXLE recombinant inbred strain rats.
Journal Exp. Anim.
Abstract Increasing exposure to environmental endocrine disruptor, xeno-estrogen, is a serious hazard to male reproductive activity. To explore possible genetic control in susceptibility to xeno-estrogen, the weight reduction of testes induced by the continuous administration of a synthetic estrogen, diethylstilbesterol, were investigated by quantitative trait analysis in LEXF and FXLE recombinant inbred strain rats, consisting of 21 independent strains, 9 of their substrains, parental F344/Stm and LE/Stm strains, and (F344 x LE)F1. For the weight of testes, one highly significant quantitative trait locus (QTL) and one significant QTL were mapped on chromosomes 7 and 1, respectively. The QTL on chromosome 7 is closely associated with c-myc. Pituitary weight and serum prolactin were also variable among recombinant inbred strains, but no QTL was detected for them in this study.
Volume 55(2)
Pages 91-5
Published 2006-4
PII JST.JSTAGE/expanim/55.91
PMID 16651691
MeSH Animals Chromosome Mapping Diethylstilbestrol / toxicity* Endocrine Disruptors / toxicity Male Organ Size / drug effects Pituitary Gland / drug effects* Prolactin / blood Rats Rats, Inbred Strains / genetics* Recombination, Genetic Testis / drug effects*
IF 1.208
Times Cited 10
Rats LEXF1A/Stm(strainID=219) LEXF1B? LEXF1C/Stm(strainID=221) LEXF2A/Stm(strainID=222) LEXF2B/Stm(strainID=223) LEXF2C/Stm(strainID=224) LEXF3/Stm(strainID=225) LEXF4/Stm(strainID=226) LEXF5/Stm(strainID=227) LEXF7A/Stm(strainID=230) LEXF7B/Stm(strainID=231) LEXF7C/Stm(strainID=232) LEXF8A/Stm(strainID=233) LEXF8D/Stm(strainID=234) LEXF9/Stm(strainID=235) LEXF10A/Stm(strainID=236) LEXF10C/Stm(strainID=238) LEXF11/Stm(strainID=239) FXLE12/Stm(strainID=250) FXLE13/Stm(strainID=251) FXLE17/Stm(strainID=255) FXLE18/Stm(strainID=256) FXLE20/Stm(strainID=258) FXLE22/Stm(strainID=260) FXLE23/Stm(strainID=261) FXLE24/Stm(strainID=262) FXLE25/Stm(strainID=263) FXLE26/Stm(strainID=264) LE/Stm(strainID=265) F344/Stm(strainID=266)