RRC ID 28069
Author Wang H, Chen X, He T, Zhou Y, Luo H.
Title Evidence for tissue-specific Jak/STAT target genes in Drosophila optic lobe development.
Journal Genetics
Abstract The evolutionarily conserved JAK/STAT pathway plays important roles in development and disease processes in humans. Although the signaling process has been well established, we know relatively little about what the relevant target genes are that mediate JAK/STAT activation during development. Here, we have used genome-wide microarrays to identify JAK/STAT targets in the optic lobes of the Drosophila brain and identified 47 genes that are positively regulated by JAK/STAT. About two-thirds of the genes encode proteins that have orthologs in humans. The STAT targets in the optic lobe appear to be different from the targets identified in other tissues, suggesting that JAK/STAT signaling may regulate different target genes in a tissue-specific manner. Functional analysis of Nop56, a cell-autonomous STAT target, revealed an essential role for this gene in the growth and proliferation of neuroepithelial stem cells in the optic lobe and an inhibitory role in lamina neurogenesis.
Volume 195(4)
Pages 1291-306
Published 2013-12-1
DOI 10.1534/genetics.113.155945
PII genetics.113.155945
PMID 24077308
PMC PMC3832274
MeSH Animals Drosophila / embryology Drosophila / genetics* Drosophila / metabolism Drosophila Proteins / genetics Drosophila Proteins / metabolism* Gene Expression Regulation, Developmental Janus Kinases / genetics Janus Kinases / metabolism* Neural Stem Cells / cytology Neural Stem Cells / metabolism Neuroepithelial Cells / cytology Neuroepithelial Cells / metabolism Neurogenesis Nuclear Proteins / genetics Nuclear Proteins / metabolism* Optic Lobe, Nonmammalian / cytology Optic Lobe, Nonmammalian / embryology Optic Lobe, Nonmammalian / metabolism* Organ Specificity RNA-Binding Proteins STAT Transcription Factors / genetics STAT Transcription Factors / metabolism*
IF 4.015
Times Cited 18
WOS Category GENETICS & HEREDITY
Resource
Drosophila 13849R-2 13849R-3