論文 - 詳細
| RRC ID | 2818 |
|---|---|
| 著者 | Lin X, Fujita M, Kanemitsu N, Kimura Y, Tambara K, Premaratne GU, Nagasawa A, Ikeda T, Tabata Y, Komeda M. |
| タイトル | Sustained-release erythropoietin ameliorates cardiac function in infarcted rat-heart without inducing polycythemia. |
| ジャーナル | Circ J |
| Abstract |
BACKGROUND:The usefulness of sustained-release erythropoietin for improving left ventricular (LV) function without polycythemia was evaluated in a rat chronic myocardial infarction model. METHODS AND RESULTS:Four weeks after left coronary artery ligation, 50 Sprague-Dawley rats were assigned to 5 groups (n=10, each). Control group had a gelatin sheet (20x20 mm) containing saline applied to the infarct area, whereas the 4 treatment groups had gelatin sheets incorporating erythropoietin 0.1 U, 1 U, 10 U and 100 U, respectively. Endpoint measurements performed at 8 weeks after the coronary ligation revealed that the fractional area change was larger for erythropoietin 1 U and 10 U than in the other 3 groups. The LV end-systolic elastance and the time constant of isovolumic relaxation were better for erythropoietin 1 U and 10 U than in the other 3 groups. The density of vessels larger than 50 microm in diameter was the highest in the erythropoietin 1 U group. The number of red blood cells was significantly increased in groups receiving erythropoietin 10 U and 100 U. CONCLUSIONS:Gelatin hydrogel sheets incorporating 1 U erythropoietin improved LV function without inducing polycythemia in a rat chronic myocardial infarction model. |
| 巻・号 | 71(1) |
| ページ | 132-7 |
| 公開日 | 2007-1-1 |
| DOI | 10.1253/circj.71.132 |
| PII | JST.JSTAGE/circj/71.132 |
| PMID | 17186991 |
| MeSH | Animals Delayed-Action Preparations Disease Models, Animal Dose-Response Relationship, Drug Echocardiography Erythropoietin / administration & dosage Erythropoietin / pharmacology Erythropoietin / therapeutic use* Gelatin Heart / drug effects Heart / physiology* Male Myocardial Infarction / drug therapy* Myocardial Infarction / physiopathology Neovascularization, Physiologic / drug effects Polycythemia / physiopathology Polycythemia / prevention & control* Rats Rats, Sprague-Dawley Ventricular Dysfunction, Left / drug therapy Ventricular Dysfunction, Left / physiopathology Ventricular Remodeling / drug effects |
| IF | 2.54 |
| 引用数 | 15 |
| WOS 分野 | CARDIAC & CARDIOVASCULAR SYSTEMS |
| リソース情報 | |
| ラット | |