論文 - 詳細
| RRC ID | 2825 |
|---|---|
| 著者 | Fuku N, Ochiai M, Terada S, Fujimoto E, Nakagama H, Tabata I. |
| タイトル | Effect of running training on DMH-induced aberrant crypt foci in rat colon. |
| ジャーナル | Med Sci Sports Exerc |
| Abstract |
PURPOSE:We examined the effects of treadmill-running training on the induction of aberrant crypt foci (ACF), which is the first step of colon cancer induction, in the colonic mucosa of rats injected with 1,2-dimethylhydrazine (DMH). METHODS:Four-week-old F344 rats (N = 38) were randomly assigned to training (19 rats) and control (19 rats) groups. After a week, all rats were given DMH (20 mg.kg(-1) body weight) once a week for 2 wk. Running training was started at age 7 wk (speed: 10 m.min(-1), 0% grade, 120 min.d(-1), 5 d.wk(-1)). After 4 wk of training, the rats were sacrificed and the colon was removed, opened, and counted for ACF with 0.2% methylene blue staining. RESULTS:Running training resulted in lower body- (P < 0.01) and adipose fat weight (P < 0.05). The numbers of ACF and total AC were significantly lower in the running training group than in the control group (P < 0.05). The occurrences of one, three, and five aberrant crypts per focus were also significantly lower in the running training group than in the control group (P < 0.05). The ratios of total AC/ACF did not significantly differ between the running training and control groups. CONCLUSIONS:The results of the present investigation suggest that low-intensity running training inhibits the DMH-induced initiation of colon ACF development. |
| 巻・号 | 39(1) |
| ページ | 70-4 |
| 公開日 | 2007-1-1 |
| DOI | 10.1249/01.mss.0000239398.78331.96 |
| PII | 00005768-200701000-00012 |
| PMID | 17218886 |
| MeSH | Animals Cell Nucleus / metabolism Colon / drug effects* Colon / metabolism Colonic Neoplasms / chemically induced Colonic Neoplasms / pathology* Dimenhydrinate / administration & dosage* Exercise Test Japan Precancerous Conditions / chemically induced Precancerous Conditions / pathology* Rats |
| IF | 4.029 |
| 引用数 | 15 |
| WOS 分野 | SPORT SCIENCES |
| リソース情報 | |
| ラット | |