| RRC ID |
28428
|
| Author |
Leyva-Castillo JM, Hener P, Michea P, Karasuyama H, Chan S, Soumelis V, Li M.
|
| Title |
Skin thymic stromal lymphopoietin initiates Th2 responses through an orchestrated immune cascade.
|
| Journal |
Nat Commun
|
| Abstract |
Thymic stromal lymphopoietin (TSLP) has emerged as a key initiator in Th2 immune responses, but the TSLP-driven immune cascade leading to Th2 initiation remains to be delineated. Here, by dissecting the cellular network triggered by mouse skin TSLP in vivo, we uncover that TSLP-promoted IL-4 induction in CD4(+) T cells in skin-draining lymph nodes is driven by an orchestrated 'DC-T-Baso-T' cascade, which represents a sequential cooperation of dendritic cells (DCs), CD4(+) T cells and basophils. Moreover, we reveal that TSLP-activated DCs prime naive CD4(+) T cells to produce IL-3 via OX40L signalling and demonstrate that the OX40L-IL-3 axis has a critical role in mediating basophil recruitment, CD4(+) T-cell expansion and Th2 priming. These findings thus add novel insights into the cellular network and signal axis underlying the initiation of Th2 immune responses.
|
| Volume |
4
|
| Pages |
2847
|
| Published |
2013-1-1
|
| DOI |
10.1038/ncomms3847
|
| PII |
ncomms3847
|
| PMID |
24284909
|
| MeSH |
Animals
Basophils / immunology
CD4-Positive T-Lymphocytes / immunology
Cytokines / genetics
Cytokines / immunology*
Dendritic Cells / immunology
Female
Interleukin-4 / immunology
Male
Mice
Mice, Inbred BALB C
Mice, Knockout
Skin / cytology
Skin / immunology*
Th2 Cells / immunology*
|
| IF |
12.121
|
| Times Cited |
76
|
|
WOS Category
|
IMMUNOLOGY
|
| Resource |
| Mice |
RBRC02298 |
