論文 - 詳細
| RRC ID | 28432 |
|---|---|
| 著者 | Horne-Debets JM, Faleiro R, Karunarathne DS, Liu XQ, Lineburg KE, Poh CM, Grotenbreg GM, Hill GR, MacDonald KP, Good MF, Renia L, Ahmed R, Sharpe AH, Wykes MN. |
| タイトル | PD-1 dependent exhaustion of CD8+ T cells drives chronic malaria. |
| ジャーナル | Cell Rep |
| Abstract |
Malaria is a highly prevalent disease caused by infection by Plasmodium spp., which infect hepatocytes and erythrocytes. Blood-stage infections cause devastating symptoms and can persist for years. Antibodies and CD4(+) T cells are thought to protect against blood-stage infections. However, there has been considerable difficulty in developing an efficacious malaria vaccine, highlighting our incomplete understanding of immunity against this disease. Here, we used an experimental rodent malaria model to show that PD-1 mediates up to a 95% reduction in numbers and functional capacity of parasite-specific CD8(+) T cells. Furthermore, in contrast to widely held views, parasite-specific CD8(+) T cells are required to control both acute and chronic blood-stage disease even when parasite-specific antibodies and CD4(+) T cells are present. Our findings provide a molecular explanation for chronic malaria that will be relevant to future malaria-vaccine design and may need consideration when vaccine development for other infections is problematic. |
| 巻・号 | 5(5) |
| ページ | 1204-13 |
| 公開日 | 2013-12-12 |
| DOI | 10.1016/j.celrep.2013.11.002 |
| PII | S2211-1247(13)00650-5 |
| PMID | 24316071 |
| MeSH | Animals CD8-Positive T-Lymphocytes / metabolism* CD8-Positive T-Lymphocytes / pathology Malaria / blood* Malaria / immunology Malaria / metabolism Mice Mice, Inbred C57BL Programmed Cell Death 1 Receptor / genetics Programmed Cell Death 1 Receptor / metabolism* |
| IF | 8.109 |
| 引用数 | 86 |
| WOS 分野 | CELL BIOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 17 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 実験動物マウス | RBRC02142 |