| RRC ID |
28440
|
| Author |
Kato H, Sakai T, Tamura K, Minoguchi S, Shirayoshi Y, Hamada Y, Tsujimoto Y, Honjo T.
|
| Title |
Functional conservation of mouse Notch receptor family members.
|
| Journal |
FEBS Lett
|
| Abstract |
All the known members of the mouse Notch receptor family were examined for their biochemical function by interaction with a DNA binding protein RBP-Jkappa. mNotch2, mNotch3 and int3 (= mNotch4) were shown to interact with RBP-Jkappa by the GST-fusion pull down assay and dominant negative competition with Epstein Barr virus nuclear antigen 2. Furthermore the intracellular region of int3 was shown to transactivate the Epstein Barr virus TP1 promoter. These results indicate that all mouse Notch family members have biochemical functions similar to mNotch1, which transduces proliferative signal by direct interaction with the DNA binding protein RBP-Jkappa.
|
| Volume |
395(2-3)
|
| Pages |
221-4
|
| Published |
1996-10-21
|
| DOI |
10.1016/0014-5793(96)01046-0
|
| PII |
0014-5793(96)01046-0
|
| PMID |
8898100
|
| MeSH |
Amino Acid Sequence
Animals
Base Sequence
Conserved Sequence
DNA Primers
Epstein-Barr Virus Nuclear Antigens / chemistry
Epstein-Barr Virus Nuclear Antigens / metabolism
Glutathione Transferase
Herpesvirus 4, Human / genetics
Membrane Proteins / biosynthesis*
Membrane Proteins / chemistry*
Mice
Molecular Sequence Data
Polymerase Chain Reaction
Promoter Regions, Genetic
Receptors, Cell Surface / biosynthesis
Receptors, Cell Surface / chemistry
Receptors, Notch
Recombinant Fusion Proteins / biosynthesis
Sequence Homology, Amino Acid
|
| IF |
3.057
|
| Times Cited |
86
|
|
WOS Category
|
BIOPHYSICS
BIOCHEMISTRY & MOLECULAR BIOLOGY
CELL BIOLOGY
|
| Resource |
| DNA material |
pEF-BOSneo-mNotch1 RAMIC (RDB06771)
pEF-BOSneoSE-mNotch2 RAMIC (RDB06772)
pEF-BOSneoSE-mNotch3 RAMIC (RDB06773)
pEF-BOSneo-mNotch4 RAMIC (RDB06774). |
