RRC ID 28446
Author Miyatani S, Shimamura K, Hatta M, Nagafuchi A, Nose A, Matsunaga M, Hatta K, Takeichi M.
Title Neural cadherin: role in selective cell-cell adhesion.
Journal Science
Abstract Cadherins are a family of Ca2+-dependent intercellular adhesion molecules. Complementary DNAs encoding mouse neural cadherin (N-cadherin) were cloned, and the cell binding specificity of this molecule was examined. Mouse N-cadherin shows 92 percent similarity in amino acid sequence to the chicken homolog, while it shows 49 percent and 43 percent similarity to epithelial cadherin and to placental cadherin of the same species, respectively. In cell binding assays, mouse N-cadherin did not cross-react with other mouse cadherins, but it did cross-react with chicken N-cadherin. The results indicate that each cadherin type confers distinct adhesive specificities on different cells, and also that the specificity of N-cadherin is conserved between mammalian and avian cells.
Volume 245(4918)
Pages 631-5
Published 1989-8-11
DOI 10.1126/science.2762814
PMID 2762814
MeSH Amino Acid Sequence Animals Antibodies, Monoclonal Antigens, Surface / genetics Antigens, Surface / physiology* Base Sequence Brain Chemistry Cell Adhesion* Cell Adhesion Molecules Chickens Cloning, Molecular DNA / genetics Embryo, Mammalian Embryo, Nonmammalian L Cells Mice Molecular Sequence Data Nerve Tissue / analysis* Nucleic Acid Hybridization Tissue Distribution Transfection
IF 41.846
Times Cited 256
DNA material Mouse N-cadherin cDNA full length (RDB01186).