| RRC ID |
28587
|
| Author |
Motomura Y, Kitamura H, Hijikata A, Matsunaga Y, Matsumoto K, Inoue H, Atarashi K, Hori S, Watarai H, Zhu J, Taniguchi M, Kubo M.
|
| Title |
The transcription factor E4BP4 regulates the production of IL-10 and IL-13 in CD4+ T cells.
|
| Journal |
Nat Immunol
|
| Abstract |
The immunoregulatory cytokine interleukin 10 (IL-10) is expressed mainly by T helper type 2 (T(H)2) cells but also by T(H)1 cells during chronic infection. Here we observed plasticity in the expression of IL-10 and IL-13 after chronic T(H)1 stimulation; furthermore, the expression of Il10 and Il13 was regulated by the transcription factor E4BP4. Chronically stimulated E4BP4-deficient (Nfil3(-/-); called 'E4bp4(-/-)' here) T(H)1 cells, regulatory T cells (T(reg) cells) and natural killer T cells (NKT cells) had attenuated expression of IL-10 and IL-13. Enforced expression of E4bp4 initiated the production of IL-10 and IL-13 by conventional T(H)1 cells. E4bp4(-/-) T(H)2 cells showed impairment of IL-10 production with no effect on IL-13. Our results indicate that E4BP4 has multiple functions in controlling the plasticity of IL-13 in T(H)1 cells and IL-10 in T(H)1 cells, T(H)2 cells, T(reg) cells and NKT cells.
|
| Volume |
12(5)
|
| Pages |
450-9
|
| Published |
2011-5-1
|
| DOI |
10.1038/ni.2020
|
| PII |
ni.2020
|
| PMID |
21460847
|
| PMC |
PMC3494493
|
| MeSH |
Animals
Autoimmune Diseases / immunology*
Basic-Leucine Zipper Transcription Factors / immunology*
CD4-Positive T-Lymphocytes / immunology*
Electrophoretic Mobility Shift Assay
Flow Cytometry
Interleukin-10 / immunology*
Interleukin-13 / immunology*
Mice
Mice, Inbred BALB C
Mice, Inbred C57BL
Mice, Knockout
Mice, Transgenic
Promoter Regions, Genetic
Specific Pathogen-Free Organisms
Transcription, Genetic
|
| IF |
20.479
|
| Times Cited |
110
|
|
WOS Category
|
IMMUNOLOGY
|
| Resource |
| DNA material |
pMx-E4BP4(Nfil3) (RDB08379) |
