Reference - Detail
| RRC ID | 28587 |
|---|---|
| Author | Motomura Y, Kitamura H, Hijikata A, Matsunaga Y, Matsumoto K, Inoue H, Atarashi K, Hori S, Watarai H, Zhu J, Taniguchi M, Kubo M. |
| Title | The transcription factor E4BP4 regulates the production of IL-10 and IL-13 in CD4+ T cells. |
| Journal | Nat Immunol |
| Abstract |
The immunoregulatory cytokine interleukin 10 (IL-10) is expressed mainly by T helper type 2 (T(H)2) cells but also by T(H)1 cells during chronic infection. Here we observed plasticity in the expression of IL-10 and IL-13 after chronic T(H)1 stimulation; furthermore, the expression of Il10 and Il13 was regulated by the transcription factor E4BP4. Chronically stimulated E4BP4-deficient (Nfil3(-/-); called 'E4bp4(-/-)' here) T(H)1 cells, regulatory T cells (T(reg) cells) and natural killer T cells (NKT cells) had attenuated expression of IL-10 and IL-13. Enforced expression of E4bp4 initiated the production of IL-10 and IL-13 by conventional T(H)1 cells. E4bp4(-/-) T(H)2 cells showed impairment of IL-10 production with no effect on IL-13. Our results indicate that E4BP4 has multiple functions in controlling the plasticity of IL-13 in T(H)1 cells and IL-10 in T(H)1 cells, T(H)2 cells, T(reg) cells and NKT cells. |
| Volume | 12(5) |
| Pages | 450-9 |
| Published | 2011-5-1 |
| DOI | 10.1038/ni.2020 |
| PII | ni.2020 |
| PMID | 21460847 |
| PMC | PMC3494493 |
| MeSH | Animals Autoimmune Diseases / immunology* Basic-Leucine Zipper Transcription Factors / immunology* CD4-Positive T-Lymphocytes / immunology* Electrophoretic Mobility Shift Assay Flow Cytometry Interleukin-10 / immunology* Interleukin-13 / immunology* Mice Mice, Inbred BALB C Mice, Inbred C57BL Mice, Knockout Mice, Transgenic Promoter Regions, Genetic Specific Pathogen-Free Organisms Transcription, Genetic |
| IF | 20.479 |
| Times Cited | 110 |
| WOS Category | IMMUNOLOGY |
| Altmetric score |
オルトメトリクス指標項目
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| The most frequently cited source | X(Twitter) |
| Total number of mentions | 21 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| DNA material | pMx-E4BP4(Nfil3) (RDB08379) |