| RRC ID |
28622
|
| 著者 |
Sakamaki K, Satou Y.
|
| タイトル |
Caspases: evolutionary aspects of their functions in vertebrates.
|
| ジャーナル |
J Fish Biol
|
| Abstract |
Caspases (cysteine-dependent aspartyl-specific protease) belong to a family of cysteine proteases that mediate proteolytic events indispensable for biological phenomena such as cell death and inflammation. The first caspase was identified as an executioner of apoptotic cell death in the worm Caenorhabditis elegans. Additionally, a large number of caspases have been identified in various animals from sponges to vertebrates. Caspases are thought to play a pivotal role in apoptosis as an evolutionarily conserved function; however, the number of caspases that can be identified is distinct for each species. This indicates that species-specific functions or diversification of physiological roles has been cultivated through caspase evolution. Furthermore, recent studies suggest that caspases are also involved in inflammation and cellular differentiation in mammals. This review highlights vertebrate caspases in their universal and divergent functions and provides insight into the physiological roles of these molecules in animals.
|
| 巻・号 |
74(4)
|
| ページ |
727-53
|
| 公開日 |
2009-3-1
|
| DOI |
10.1111/j.1095-8649.2009.02184.x
|
| PII |
JFB2184
|
| PMID |
20735596
|
| PMC |
PMC2779465
|
| MeSH |
Animals
Apoptosis / physiology
Biological Evolution*
Caspases / metabolism*
Cell Differentiation / physiology
Humans
Inflammation / enzymology
Phylogeny
|
| IF |
1.497
|
| 引用数 |
47
|
|
WOS 分野
|
FISHERIES
MARINE & FRESHWATER BIOLOGY
|
| リソース情報 |
| 遺伝子材料 |
MPMGp1174L1811Q (Paracentrotus lividus caspase-8) (RDB08081) |
