| RRC ID |
28855
|
| 著者 |
Lu B, Shao L, Feng S, Wang T, Zhong Y.
|
| タイトル |
The β-alanyl-monoamine synthase ebony is regulated by schizophrenia susceptibility gene dysbindin in Drosophila.
|
| ジャーナル |
Sci China Life Sci
|
| Abstract |
The Drosophila homolog of schizophrenia susceptibility gene dysbindin (Ddysb) affects a range of behaviors through regulation of multiple neurotransmitter signals, including dopamine activity. To gain insights into mechanisms underlying Ddysb-dependent regulation of dopamine signal, we investigated interaction between Ddysb and Ebony, the Drosophila β-alanyl-monoamine synthase involved in dopamine recycling. We found that Ddysb was capable of regulating expression of Ebony in a bi-directional manner and its subcellular distribution. Such regulation is confined to glial cells. The expression level of ebony and its accumulation in glial soma depend positively on Ddysb activity, whereas its distribution in glial processes is bound to be reduced in response to any alterations of Ddysb from the normal control level, either an increase or decrease. An optimal binding ratio between Dysb and Ebony might contribute to such non-linear effects. Thus, Ddysb-dependent regulation of Ebony could be one of the mechanisms that mediate dopamine signal.
|
| 巻・号 |
57(1)
|
| ページ |
46-51
|
| 公開日 |
2014-1-1
|
| DOI |
10.1007/s11427-013-4595-9
|
| PMID |
24399135
|
| MeSH |
Animals
Carrier Proteins / genetics*
DNA-Binding Proteins / genetics*
Drosophila
Drosophila Proteins / genetics*
Dysbindin
Dystrophin-Associated Proteins
Genetic Predisposition to Disease*
Schizophrenia / genetics*
|
| IF |
4.611
|
| 引用数 |
2
|
|
WOS 分野
|
BIOLOGY
|
| リソース情報 |
| ショウジョウバエ |
DGRC#141729
6856R-1
6856R-2 |
