RRC ID 29008
著者 Tsujioka M, Machesky LM, Cole SL, Yahata K, Inouye K.
タイトル A unique talin homologue with a villin headpiece-like domain is required for multicellular morphogenesis in Dictyostelium.
ジャーナル Curr Biol
Abstract Molecules involved in the interaction between the extracellular matrix, cell membrane and cytoskeleton are of central importance in morphogenesis. Talin is a large cytoskeletal protein with a modular structure consisting of an amino-terminal membrane-interacting domain, with sequence similarities to members of the band 4.1 family, and a carboxy-terminal region containing F-actin-binding and vinculin-binding domains [1] [2]. It also interacts with the cytoplasmic tail of beta integrins which, on the external face of the membrane, bind to extracellular matrix proteins [3]. The possible roles of talin in multicellular morphogenesis in development remain largely unexplored. In Dictyostelium, a eukaryotic microorganism capable of multicellular morphogenesis, a talin homologue (TALA) has previously been identified and shown to play an important role in cell-to-substrate adhesion and maintenance of normal elastic properties of the cell [4] [5] [6]. Here, we describe a second talin homologue (TALB) that is required for multicellular morphogenesis in the development of Dictyostelium. Unlike any other talin characterised to date, it contains an additional carboxy-terminal domain homologous to the villin headpiece.
巻・号 9(7)
ページ 389-92
公開日 1999-4-8
DOI 10.1016/s0960-9822(99)80169-9
PII S0960-9822(99)80169-9
PMID 10209124
MeSH Amino Acid Sequence Animals Binding Sites Carrier Proteins / genetics* DNA, Complementary / chemistry DNA, Complementary / genetics Dictyostelium / chemistry Dictyostelium / genetics* Dictyostelium / growth & development Gene Expression Regulation, Developmental Microfilament Proteins / genetics* Molecular Sequence Data Protein Isoforms / genetics Sequence Alignment Sequence Analysis, DNA Sequence Homology, Amino Acid Talin / genetics*
IF 9.601
引用数 48
WOS 分野 BIOCHEMISTRY & MOLECULAR BIOLOGY CELL BIOLOGY
リソース情報
細胞性粘菌 S00119 S00120