RRC ID |
29008
|
著者 |
Tsujioka M, Machesky LM, Cole SL, Yahata K, Inouye K.
|
タイトル |
A unique talin homologue with a villin headpiece-like domain is required for multicellular morphogenesis in Dictyostelium.
|
ジャーナル |
Curr Biol
|
Abstract |
Molecules involved in the interaction between the extracellular matrix, cell membrane and cytoskeleton are of central importance in morphogenesis. Talin is a large cytoskeletal protein with a modular structure consisting of an amino-terminal membrane-interacting domain, with sequence similarities to members of the band 4.1 family, and a carboxy-terminal region containing F-actin-binding and vinculin-binding domains [1] [2]. It also interacts with the cytoplasmic tail of beta integrins which, on the external face of the membrane, bind to extracellular matrix proteins [3]. The possible roles of talin in multicellular morphogenesis in development remain largely unexplored. In Dictyostelium, a eukaryotic microorganism capable of multicellular morphogenesis, a talin homologue (TALA) has previously been identified and shown to play an important role in cell-to-substrate adhesion and maintenance of normal elastic properties of the cell [4] [5] [6]. Here, we describe a second talin homologue (TALB) that is required for multicellular morphogenesis in the development of Dictyostelium. Unlike any other talin characterised to date, it contains an additional carboxy-terminal domain homologous to the villin headpiece.
|
巻・号 |
9(7)
|
ページ |
389-92
|
公開日 |
1999-4-8
|
DOI |
10.1016/s0960-9822(99)80169-9
|
PII |
S0960-9822(99)80169-9
|
PMID |
10209124
|
MeSH |
Amino Acid Sequence
Animals
Binding Sites
Carrier Proteins / genetics*
DNA, Complementary / chemistry
DNA, Complementary / genetics
Dictyostelium / chemistry
Dictyostelium / genetics*
Dictyostelium / growth & development
Gene Expression Regulation, Developmental
Microfilament Proteins / genetics*
Molecular Sequence Data
Protein Isoforms / genetics
Sequence Alignment
Sequence Analysis, DNA
Sequence Homology, Amino Acid
Talin / genetics*
|
IF |
9.601
|
引用数 |
48
|
WOS 分野
|
BIOCHEMISTRY & MOLECULAR BIOLOGY
CELL BIOLOGY
|
リソース情報 |
細胞性粘菌 |
S00119
S00120 |