論文 - 詳細
| RRC ID | 29008 |
|---|---|
| 著者 | Tsujioka M, Machesky LM, Cole SL, Yahata K, Inouye K. |
| タイトル | A unique talin homologue with a villin headpiece-like domain is required for multicellular morphogenesis in Dictyostelium. |
| ジャーナル | Curr Biol |
| Abstract |
Molecules involved in the interaction between the extracellular matrix, cell membrane and cytoskeleton are of central importance in morphogenesis. Talin is a large cytoskeletal protein with a modular structure consisting of an amino-terminal membrane-interacting domain, with sequence similarities to members of the band 4.1 family, and a carboxy-terminal region containing F-actin-binding and vinculin-binding domains [1] [2]. It also interacts with the cytoplasmic tail of beta integrins which, on the external face of the membrane, bind to extracellular matrix proteins [3]. The possible roles of talin in multicellular morphogenesis in development remain largely unexplored. In Dictyostelium, a eukaryotic microorganism capable of multicellular morphogenesis, a talin homologue (TALA) has previously been identified and shown to play an important role in cell-to-substrate adhesion and maintenance of normal elastic properties of the cell [4] [5] [6]. Here, we describe a second talin homologue (TALB) that is required for multicellular morphogenesis in the development of Dictyostelium. Unlike any other talin characterised to date, it contains an additional carboxy-terminal domain homologous to the villin headpiece. |
| 巻・号 | 9(7) |
| ページ | 389-92 |
| 公開日 | 1999-4-8 |
| DOI | 10.1016/s0960-9822(99)80169-9 |
| PII | S0960-9822(99)80169-9 |
| PMID | 10209124 |
| MeSH | Amino Acid Sequence Animals Binding Sites Carrier Proteins / genetics* DNA, Complementary / chemistry DNA, Complementary / genetics Dictyostelium / chemistry Dictyostelium / genetics* Dictyostelium / growth & development Gene Expression Regulation, Developmental Microfilament Proteins / genetics* Molecular Sequence Data Protein Isoforms / genetics Sequence Alignment Sequence Analysis, DNA Sequence Homology, Amino Acid Talin / genetics* |
| IF | 9.601 |
| 引用数 | 48 |
| WOS 分野 | BIOCHEMISTRY & MOLECULAR BIOLOGY CELL BIOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 各媒体での言及数の合計 | 0 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 細胞性粘菌 | S00119 S00120 |