Reference - Detail
|Author||Mariani G, Calastrini C, Carinci F, Bergamini L, Calastrini F, Stabellini G.|
|Title||Ultrastructural and histochemical features of the ground substance in cyclosporin A-induced gingival overgrowth.|
The overgrowth-affected gingiva of patients treated with cyclosporin A after kidney transplant was examined with ultrastructural and histochemical methods to evaluate the involvement of connective tissue. Gingival overgrowth has the same clinical signs as local edema. The ultrastructural study showed that the dimensional increase was largely due to increased production of amorphous ground substance by fibroblasts, possibly resulting from an increased release of histamine by mast cells. The histochemical data revealed that the affected tissues contained higher levels of glycosaminoglycans and that cyclosporin A induced comparably high levels of glycosaminoglycans in in vitro cultures of fibroblasts obtained from normal gingiva. The combination of ultrastructural and histochemical data, therefore, strongly suggests that the response of the connective tissue in gingival overgrowth cannot be ignored and may be the main cause of the observed pathological condition.
|MeSH||Alcian Blue Capillaries / drug effects Capillaries / ultrastructure Chondroitin Sulfates / analysis Coloring Agents Connective Tissue / drug effects Connective Tissue / ultrastructure Cyclosporine / adverse effects* Dermatan Sulfate / analysis Edema / chemically induced Edema / pathology Epithelium / drug effects Epithelium / ultrastructure Fibroblasts / drug effects Fibroblasts / ultrastructure Gingiva / blood supply Gingiva / drug effects Gingiva / ultrastructure* Gingival Hyperplasia / chemically induced Gingival Hyperplasia / pathology* Glycosaminoglycans / analysis Heparin / analysis Heparitin Sulfate / analysis Histamine Release Humans Immunosuppressive Agents / adverse effects* Keratan Sulfate / analysis Kidney Transplantation Mast Cells / drug effects Mast Cells / ultrastructure Tetrapyrroles*|
|WOS Category||DENTISTRY, ORAL SURGERY & MEDICINE|
|DNA material||pbovLIF (RDB01660)|