Reference - Detail
| RRC ID | 29201 |
|---|---|
| Author | Nishizawa M, Hayakawa Y, Yanaihara N, Okamoto H. |
| Title | Nucleotide sequence divergence and functional constraint in VIP precursor mRNA evolution between human and rat. |
| Journal | FEBS Lett |
| Abstract |
The nucleotide sequence analysis of cloned cDNA for VIP precursor from rat cerebral cortex reveals that the precursor contains both rat VIP and PHI-27. The deduced primary structure of rat VIP is identical with human VIP. The amino acid sequence of rat PHI-27 differs by 4 amino acids from human PHM-27. When each VIP precursor is divided functionally into 6 domains, the amino acid sequence homology between rat and human precursors ranges from 69 to 100%. In contrast, any domain exhibits an essentially equal degree of nucleotide sequence homology. |
| Volume | 183(1) |
| Pages | 55-9 |
| Published | 1985-4-8 |
| DOI | 10.1016/0014-5793(85)80953-4 |
| PII | 0014-5793(85)80953-4 |
| PMID | 3838518 |
| MeSH | Amino Acid Sequence Animals Base Sequence Biological Evolution* Cerebral Cortex / analysis DNA DNA, Recombinant Humans Male Nucleic Acid Hybridization Peptide PHI Peptides / genetics Protein Precursors / genetics* RNA, Messenger* Rats Rats, Inbred Strains Vasoactive Intestinal Peptide / genetics* |
| IF | 3.057 |
| Times Cited | 227 |
| WOS Category | BIOPHYSICS BIOCHEMISTRY & MOLECULAR BIOLOGY CELL BIOLOGY |
| Resource | |
| DNA material | pVIP rat-B (RDB01214) |