論文 - 詳細
| RRC ID | 29294 |
|---|---|
| 著者 | Ueki M, Koshiro N, Aono H, Kawatani M, Uramoto M, Kawasaki H, Osada H. |
| タイトル | Isolation of new polyketide metabolites, linearolides A and B, from Streptomyces sp. RK95-74. |
| ジャーナル | J Antibiot (Tokyo) |
| Abstract |
Although all Streptomyces strains are now thought to have 20-30 gene clusters for secondary metabolite biosynthesis, we cannot actually identify so many kinds of metabolites from one strain by conventional methods. Using Streptomyces sp. RK95-74, previously found as a cytotrienin producer, we searched new metabolites other than cytotrienin derivatives. Following the cultivation with new media and the peak-guided fractionation, we have found new compounds with new polyketide scaffold, named linearolides A and B. |
| 巻・号 | 66(6) |
| ページ | 333-7 |
| 公開日 | 2013-6-1 |
| DOI | 10.1038/ja.2013.19 |
| PII | ja201319 |
| PMID | 23531987 |
| PMC | PMC3696930 |
| MeSH | Animals Antineoplastic Agents, Phytogenic / isolation & purification* Antineoplastic Agents, Phytogenic / pharmacology Chemical Fractionation / methods Culture Media / chemistry Disk Diffusion Antimicrobial Tests Escherichia coli / drug effects HL-60 Cells HeLa Cells Humans Inhibitory Concentration 50 MCF-7 Cells Molecular Conformation Multigene Family Polyketides / chemistry Polyketides / isolation & purification* Polyketides / pharmacology Pseudomonas aeruginosa / drug effects Staphylococcus aureus / drug effects Streptomyces / chemistry* Streptomyces / genetics Streptomyces / isolation & purification U937 Cells |
| IF | 2.668 |
| 引用数 | 1 |
| WOS 分野 | BIOTECHNOLOGY & APPLIED MICROBIOLOGY IMMUNOLOGY MICROBIOLOGY PHARMACOLOGY & PHARMACY |
| リソース情報 | |
| 一般微生物 | JCM 1542 JCM 7255 |