論文 - 詳細
| RRC ID | 29320 |
|---|---|
| 著者 | Kawada M, Inoue H, Ohba S, Hatano M, Amemiya M, Hayashi C, Usami I, Abe H, Watanabe T, Kinoshita N, Igarashi M, Masuda T, Ikeda D, Nomoto A. |
| タイトル | Intervenolin, a new antitumor compound with anti-Helicobacter pylori activity, from Nocardia sp. ML96-86F2. |
| ジャーナル | J Antibiot (Tokyo) |
| Abstract |
Because stromal cells can regulate the growth and metastasis of tumor cells, a compound that modulates the interaction between the stromal cells and the tumor cells can control the tumor progression. In the course of our screening for such a compound, we have isolated a new compound, intervenolin, from the culture broth of Nocardia sp. ML96-86F2. Intervenolin inhibits the growth of human gastric and colorectal cancer cell lines in the coculture with the respective organ-derived stromal cells more strongly than that of the cancer cells cultured alone. Intervenolin shows antitumor effect against a xenograft model of human colorectal cancer cells in vivo. Furthermore, intervenolin exerts selective anti-Helicobacter pylori effect. |
| 巻・号 | 66(9) |
| ページ | 543-8 |
| 公開日 | 2013-9-1 |
| DOI | 10.1038/ja.2013.42 |
| PII | ja201342 |
| PMID | 23632919 |
| MeSH | Animals Anti-Bacterial Agents / isolation & purification Anti-Bacterial Agents / pharmacology* Antibiotics, Antineoplastic / isolation & purification Antibiotics, Antineoplastic / pharmacology* Cell Line, Tumor Cell Survival / drug effects Coculture Techniques Colorectal Neoplasms / drug therapy Disease Models, Animal Female Helicobacter pylori / drug effects* Humans Mice Mice, Inbred BALB C Mice, Inbred ICR Microbial Sensitivity Tests Nocardia / chemistry* Quinolones / isolation & purification Quinolones / pharmacology* Stromal Cells / drug effects |
| IF | 2.668 |
| 引用数 | 15 |
| WOS 分野 | PHARMACOLOGY & PHARMACY BIOTECHNOLOGY & APPLIED MICROBIOLOGY MICROBIOLOGY IMMUNOLOGY |
| リソース情報 | |
| 一般微生物 | JCM 5803 JCM 12093 JCM 12095 |
| ヒト・動物細胞 | MKN7(RCB0999) MKN74(RCB1002) |