Reference - Detail
| RRC ID | 29491 |
|---|---|
| Author | Bai H, Li W, Zhao H, Anzai Y, Li H, Guo H, Kato F, Koike K. |
| Title | Isolation and structural elucidation of novel cholestane glycosides and spirostane saponins from Polygonatum odoratum. |
| Journal | Steroids |
| Abstract |
Much attention has been paid to cholestane-type steroidal glycosides because of their importance from the perspectives of both chemical diversity and significant biological activities. A phytochemical investigation of the rhizomes of Polygonatum odoratum (Liliaceae) resulted in the isolation of three novel cholestane-type steroidal glycosides (1-3) with unique Δ(14,16)-unsaturated D-ring structures as well as two novel spirostane-type steroidal saponins (4 and 5) and three known steroidal glycosides (6-8). Their structures were determined by various spectroscopic methods and chemical reactions. Steroidal saponin 7 showed significant antifungal activity against Candida albicans JCM1542 (MIC 3.1 μg/mL) and Aspergillus fumigatus JCM1738 (MIC 6.3 μg/mL). |
| Volume | 80 |
| Pages | 7-14 |
| Published | 2014-2-1 |
| DOI | 10.1016/j.steroids.2013.11.013 |
| PII | S0039-128X(13)00266-3 |
| PMID | 24291419 |
| MeSH | Cholestanes / chemistry* Cholestanes / isolation & purification Glycosides / chemistry* Glycosides / isolation & purification Molecular Structure Plant Extracts / chemistry* Polygonatum / chemistry* Saponins / chemistry* Saponins / isolation & purification Spirostans / chemistry* Spirostans / isolation & purification Stereoisomerism |
| IF | 1.948 |
| Times Cited | 14 |
| WOS Category | BIOCHEMISTRY & MOLECULAR BIOLOGY ENDOCRINOLOGY & METABOLISM |
| Resource | |
| General Microbes | JCM 1542 JCM 1738 |