論文 - 詳細
| RRC ID | 29675 |
|---|---|
| 著者 | Greer EL, Beese-Sims SE, Brookes E, Spadafora R, Zhu Y, Rothbart SB, Aristizábal-Corrales D, Chen S, Badeaux AI, Jin Q, Wang W, Strahl BD, Colaiácovo MP, Shi Y. |
| タイトル | A histone methylation network regulates transgenerational epigenetic memory in C. elegans. |
| ジャーナル | Cell Rep |
| Abstract |
How epigenetic information is transmitted from generation to generation remains largely unknown. Deletion of the C. elegans histone H3 lysine 4 dimethyl (H3K4me2) demethylase spr-5 leads to inherited accumulation of the euchromatic H3K4me2 mark and progressive decline in fertility. Here, we identified multiple chromatin-modifying factors, including H3K4me1/me2 and H3K9me3 methyltransferases, an H3K9me3 demethylase, and an H3K9me reader, which either suppress or accelerate the progressive transgenerational phenotypes of spr-5 mutant worms. Our findings uncover a network of chromatin regulators that control the transgenerational flow of epigenetic information and suggest that the balance between euchromatic H3K4 and heterochromatic H3K9 methylation regulates transgenerational effects on fertility. |
| 巻・号 | 7(1) |
| ページ | 113-26 |
| 公開日 | 2014-4-10 |
| DOI | 10.1016/j.celrep.2014.02.044 |
| PII | S2211-1247(14)00158-2 |
| PMID | 24685137 |
| PMC | PMC4012616 |
| MeSH | Animals Caenorhabditis elegans / genetics* Caenorhabditis elegans / metabolism Caenorhabditis elegans Proteins / genetics Chromatin / genetics Chromatin / metabolism Epigenesis, Genetic Epigenomics Histones / genetics* Histones / metabolism* Methylation Methyltransferases / metabolism Oxidoreductases, N-Demethylating / genetics |
| IF | 8.109 |
| 引用数 | 81 |
| WOS 分野 | CELL BIOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 11 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 線虫 | set-26(tm3526) jmjd-2(tm2966) jmjd-4(tm965) jmjd-1.2(tm3713) psr-1(tm464) jmjd-3.3(tm3197) jmjd-3.2(tm3121) |