RRC ID 29675
Author Greer EL, Beese-Sims SE, Brookes E, Spadafora R, Zhu Y, Rothbart SB, Aristizábal-Corrales D, Chen S, Badeaux AI, Jin Q, Wang W, Strahl BD, Colaiácovo MP, Shi Y.
Title A histone methylation network regulates transgenerational epigenetic memory in C. elegans.
Journal Cell Rep
Abstract How epigenetic information is transmitted from generation to generation remains largely unknown. Deletion of the C. elegans histone H3 lysine 4 dimethyl (H3K4me2) demethylase spr-5 leads to inherited accumulation of the euchromatic H3K4me2 mark and progressive decline in fertility. Here, we identified multiple chromatin-modifying factors, including H3K4me1/me2 and H3K9me3 methyltransferases, an H3K9me3 demethylase, and an H3K9me reader, which either suppress or accelerate the progressive transgenerational phenotypes of spr-5 mutant worms. Our findings uncover a network of chromatin regulators that control the transgenerational flow of epigenetic information and suggest that the balance between euchromatic H3K4 and heterochromatic H3K9 methylation regulates transgenerational effects on fertility.
Volume 7(1)
Pages 113-26
Published 2014-4-10
DOI 10.1016/j.celrep.2014.02.044
PII S2211-1247(14)00158-2
PMID 24685137
PMC PMC4012616
MeSH Animals Caenorhabditis elegans / genetics* Caenorhabditis elegans / metabolism Caenorhabditis elegans Proteins / genetics Chromatin / genetics Chromatin / metabolism Epigenesis, Genetic Epigenomics Histones / genetics* Histones / metabolism* Methylation Methyltransferases / metabolism Oxidoreductases, N-Demethylating / genetics
IF 8.109
Times Cited 81
C.elegans set-26(tm3526) jmjd-2(tm2966) jmjd-4(tm965) jmjd-1.2(tm3713) psr-1(tm464) jmjd-3.3(tm3197) jmjd-3.2(tm3121)