| RRC ID |
29678
|
| 著者 |
Xu J, Kusakabe T, Yamamoto K, Suetsugu Y, Mon H, Li Z, Zhu L, Iiyama K, Banno Y, Yoshimura K, Lee JM.
|
| タイトル |
A novel third chromosomal locus controls susceptibility to Autographa californica multiple nucleopolyhedrovirus in the silkworm, Bombyx mori.
|
| ジャーナル |
Appl Microbiol Biotechnol
|
| Abstract |
Baculovirus demonstrates specific infection spectrums and thus one certain host exhibits particular response to single baculovirus isolate. Autographa californica multiple nucleopolyhedrovirus (AcMNPV) is considered to be not an innate pathogen to Bombyx mori, but some silkworm strains have been identified to be permissive to AcMNPV, indicating the positive or negative involvement of certain host factors in baculovirus replications in vivo. To provide a fundamental knowledge of this process, we performed large-scale screening to investigate the responses of 448 silkworm strains against recombinant AcMNPV inoculation. By genetic analysis between permissive and resistant strains identified, we further confirmed that a potential corresponding locus on chromosome 3 regulates host responses to AcMNPV in silkworm. Additionally, we found that it is available for AcMNPV-silkworm baculovirus expression vector system to produce proteins of interest.
|
| 巻・号 |
98(7)
|
| ページ |
3049-58
|
| 公開日 |
2014-4-1
|
| DOI |
10.1007/s00253-013-5437-1
|
| PMID |
24337396
|
| MeSH |
Animals
Bombyx / genetics*
Bombyx / virology*
Genes, Insect
Genetic Loci*
Genetic Testing
Nucleopolyhedroviruses / growth & development
Nucleopolyhedroviruses / physiology*
Virus Replication*
|
| IF |
3.53
|
| 引用数 |
2
|
|
WOS 分野
|
BIOTECHNOLOGY & APPLIED MICROBIOLOGY
|
| リソース情報 |
| カイコ |
448 strains |
