論文 - 詳細
| RRC ID | 2985 |
|---|---|
| 著者 | Maeno Y, Nakazawa S, Yamamoto N, Shinzato M, Nagashima S, Tanaka K, Sasaki J, Rittling SR, Denhardt DT, Uede T, Taniguchi K. |
| タイトル | Osteopontin participates in Th1-mediated host resistance against nonlethal malaria parasite Plasmodium chabaudi chabaudi infection in mice. |
| ジャーナル | Infect Immun |
| Abstract |
Osteopontin (OPN) knockout mice (OPN-KO mice) died of Plasmodium chabaudi chabaudi infection, although wild-type (WT) mice had self-limiting infections. OPN was detected in the WT mice at 2 days postinfection. OPN-KO mice produced significantly smaller amounts of interleukin-12 and gamma interferon than WT mice produced. These results suggested that OPN is involved in Th1-mediated immunity against malaria infection. |
| 巻・号 | 74(4) |
| ページ | 2423-7 |
| 公開日 | 2006-4-1 |
| DOI | 10.1128/IAI.74.4.2423-2427.2006 |
| PII | 74/4/2423 |
| PMID | 16552072 |
| PMC | PMC1418913 |
| MeSH | Animals Flow Cytometry Immunity, Innate / genetics Interferon-gamma / blood Interleukin-12 / blood Kinetics Malaria / blood Malaria / genetics Malaria / immunology* Malaria / mortality Mice Mice, Inbred C57BL Mice, Knockout Osteopontin Plasmodium chabaudi / immunology* RNA, Messenger / biosynthesis Sialoglycoproteins / biosynthesis Sialoglycoproteins / deficiency Sialoglycoproteins / genetics Sialoglycoproteins / physiology* Th1 Cells / immunology* Th1 Cells / parasitology |
| IF | 3.201 |
| 引用数 | 14 |
| WOS 分野 | INFECTIOUS DISEASES IMMUNOLOGY |
| リソース情報 | |
| 病原微生物 | P. chabaudi chabaudi ? |