| RRC ID |
3000
|
| 著者 |
Myoken Y, Kyo T, Sugata T, Murayama SY, Mikami Y.
|
| タイトル |
Breakthrough fungemia caused by fluconazole-resistant Candida albicans with decreased susceptibility to voriconazole in patients with hematologic malignancies.
|
| ジャーナル |
Haematologica
|
| Abstract |
A 7-year retrospective analysis of candidemia in patients with hematologic malignancies demonstrated that ten patients, who received itraconazole and fluconazole during neutropenia, developed breakthrough fungemia caused by fluconazole-resistant Candida albicans (C. albicans) with decreased susceptibility to voriconazole. Eight of these ten patients died of candidemia despite amphotericin B administration. Karyotype analysis of C. albicans isolates revealed that all isolates were genetically unrelated? Our findings suggest that blood isolates of C. albicans in neutropenic patients receiving azoles could be azole cross-resistant, and that the patients should be treated by other antifungals such as echinocandins.
|
| 巻・号 |
91(2)
|
| ページ |
287-8
|
| 公開日 |
2006-2-1
|
| PMID |
16461328
|
| MeSH |
Candida albicans*
Candidiasis / etiology
Drug Resistance*
Fluconazole / therapeutic use*
Fungemia / etiology*
Hematologic Neoplasms / complications*
Humans
Pyrimidines / therapeutic use
Retrospective Studies
Triazoles / therapeutic use
Voriconazole
|
| IF |
7.116
|
| 引用数 |
10
|
|
WOS 分野
|
HEMATOLOGY
|
| リソース情報 |
| 病原微生物 |
C. albicans? |
