Reference - Detail
RRC ID | 30087 |
---|---|
Author | Whalen WA, Berg CM. |
Title | Gratuitous repression of avtA in Escherichia coli and Salmonella typhimurium. |
Journal | J Bacteriol |
Abstract |
avtA , which encodes transaminase C (alanine-valine transaminase), is repressed by excess-L-alanine or L-leucine, and also by limitation for any of a number of amino acids in Escherichia coli and Salmonella typhimurium. Amino acid limitation causes repression by promoting the accumulation of L-alanine or L-leucine or both. avtA is also repressed by L-alpha-aminobutyric acid and other nonprotein amino acids which are structurally similar to L-alanine. We hypothesize that L-alanine and L-alpha-aminobutyric acid, whose syntheses are catalyzed by transaminase C, are the true corepressors of avtA . Repression by structural analogs of the true corepressors is termed gratuitous repression. |
Volume | 158(2) |
Pages | 571-4 |
Published | 1984-5-1 |
DOI | 10.1128/jb.158.2.571-574.1984 |
PMID | 6373721 |
PMC | PMC215466 |
MeSH | Alanine / pharmacology Amino Acids / pharmacology* Aminobutyrates / pharmacology Enzyme Repression / drug effects Escherichia coli / enzymology* Escherichia coli / genetics Genes, Bacterial Leucine / pharmacology Salmonella typhimurium / enzymology* Salmonella typhimurium / genetics Structure-Activity Relationship Transaminases / biosynthesis* Transaminases / genetics |
IF | 3.006 |
Times Cited | 15 |
WOS Category | MICROBIOLOGY |
Resource | |
Prokaryotes E. coli | ME8311 ME8273 ME8312 ME8334 ME8335 ME8336 ME8337 ME8339 ME8340 ME8341 ME8342 ME8343 ME8352 ME8355 ME8356 ME8345 ME8360 ME8359 ME8350 ME8344 ME8346 ME8347 ME8349 ME8351 ME8353 ME8354 ME8361 ME8348 ME8748 |