Reference - Detail
| RRC ID | 30562 |
|---|---|
| Author | Kojima Y, Wakita J, Inayoshi Y, Suzuki R, Yamada Y, Kaneoka H, Nishijima K, Iijima S. |
| Title | Galactosylation of human erythropoietin produced by chimeric chickens expressing galactosyltransferase. |
| Journal | J Biosci Bioeng |
| Abstract |
Human erythropoietin produced in the egg white of chimeric chicken contains N-glycan with lower amounts of terminal galactose and sialic acid; therefore, the chicken galactosyltransferase gene was introduced together with the human erythropoietin gene by a retroviral vector. We found that erythropoietin accumulated in the egg white was partially galactosylated. |
| Volume | 117(6) |
| Pages | 676-9 |
| Published | 2014-6-1 |
| DOI | 10.1016/j.jbiosc.2013.11.010 |
| PII | S1389-1723(13)00432-5 |
| PMID | 24355574 |
| MeSH | Animals Animals, Genetically Modified / genetics Avian Proteins / biosynthesis Avian Proteins / genetics Chick Embryo Chickens / genetics* Egg Proteins / metabolism Erythropoietin / genetics Erythropoietin / metabolism* Galactose / metabolism* Galactosyltransferases / biosynthesis Galactosyltransferases / genetics Glycosylation Humans Plasmids Protein Processing, Post-Translational* Vesiculovirus / genetics |
| IF | 2.366 |
| Times Cited | 5 |
| WOS Category | FOOD SCIENCE & TECHNOLOGY BIOTECHNOLOGY & APPLIED MICROBIOLOGY |
| Resource | |
| Chicken / Quail | |