Reference - Detail
| RRC ID | 30637 |
|---|---|
| Author | Melo JA, Ruvkun G. |
| Title | Inactivation of conserved C. elegans genes engages pathogen- and xenobiotic-associated defenses. |
| Journal | Cell |
| Abstract |
The nematode C. elegans is attracted to nutritious bacteria and is repelled by pathogens and toxins. Here we show that RNAi and toxin-mediated disruption of core cellular activities, including translation, respiration, and protein turnover, stimulate behavioral avoidance of normally attractive bacteria. RNAi of these and other essential processes induces expression of detoxification and innate immune effectors, even in the absence of toxins or pathogens. Disruption of core processes in non-neuronal tissues was sufficient to stimulate aversion behavior, revealing a neuroendocrine axis of control that additionally required serotonergic and Jnk kinase signaling pathways. We propose that surveillance pathways overseeing core cellular activities allow animals to detect invading pathogens that deploy toxins and virulence factors to undermine vital host functions. Variation in cellular surveillance and endocrine pathways controlling behavior, detoxification, and immunity selected by past toxin or microbial interactions could underlie aberrant responses to foods, medicines, and microbes. |
| Volume | 149(2) |
| Pages | 452-66 |
| Published | 2012-4-13 |
| DOI | 10.1016/j.cell.2012.02.050 |
| PII | S0092-8674(12)00346-7 |
| PMID | 22500807 |
| PMC | PMC3613046 |
| MeSH | Animals Bacteria / metabolism Bacterial Toxins Caenorhabditis elegans / cytology Caenorhabditis elegans / immunology Caenorhabditis elegans / microbiology* Caenorhabditis elegans / physiology* Cell Physiological Phenomena Host-Pathogen Interactions* Immunity, Innate MAP Kinase Signaling System Neurosecretory Systems / metabolism RNA Interference Signal Transduction Xenobiotics / metabolism* |
| IF | 38.637 |
| Times Cited | 185 |
| WOS Category | BIOCHEMISTRY & MOLECULAR BIOLOGY CELL BIOLOGY |
| Altmetric score |
オルトメトリクス指標項目
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| The most frequently cited source | Patent(IFI CLAIMS) |
| Total number of mentions | 19 |
| Altmetric score changes over past 6months | 3.0 |
| Resource | |
| C.elegans | tm4067 |