Reference - Detail
| RRC ID | 30638 |
|---|---|
| Author | Shen Y, Wollam J, Magner D, Karalay O, Antebi A. |
| Title | A steroid receptor-microRNA switch regulates life span in response to signals from the gonad. |
| Journal | Science |
| Abstract |
Although the gonad primarily functions in procreation, it also affects animal life span. Here, we show that removal of the Caenorhabditis elegans germ line triggers a switch in the regulatory state of the organism to promote longevity, co-opting components involved in larval developmental timing circuits. These components include the DAF-12 steroid receptor, which is involved in the larval stage two-to-stage three (L2-L3) transition and up-regulates members of the let-7 microRNA (miRNA) family. The miRNAs target an early larval nuclear factor lin-14 and akt-1/kinase, thereby stimulating DAF-16/FOXO signaling to extend life. Our studies suggest that metazoan life span is coupled to the gonad through elements of a developmental timer. |
| Volume | 338(6113) |
| Pages | 1472-6 |
| Published | 2012-12-14 |
| DOI | 10.1126/science.1228967 |
| PII | 338/6113/1472 |
| PMID | 23239738 |
| PMC | PMC3909774 |
| MeSH | Animals Caenorhabditis elegans / genetics Caenorhabditis elegans / growth & development Caenorhabditis elegans / physiology* Caenorhabditis elegans Proteins / genetics Caenorhabditis elegans Proteins / physiology* Forkhead Transcription Factors Gene Expression Regulation, Developmental Germ Cells / metabolism Gonads / metabolism* Larva / genetics Larva / growth & development Larva / physiology Longevity / genetics Longevity / physiology* MicroRNAs / genetics MicroRNAs / metabolism* Nuclear Proteins / genetics Nuclear Proteins / physiology Proto-Oncogene Proteins c-akt / genetics Proto-Oncogene Proteins c-akt / physiology Receptors, Cytoplasmic and Nuclear / genetics Receptors, Cytoplasmic and Nuclear / physiology* Receptors, Steroid / genetics Receptors, Steroid / physiology* Signal Transduction Transcription Factors / genetics Transcription Factors / physiology |
| IF | 41.846 |
| Times Cited | 65 |
| WOS Category | CELL BIOLOGY |
| Resource | |
| C.elegans | tm1011 |