論文 - 詳細
| RRC ID | 30642 |
|---|---|
| 著者 | Conine CC, Moresco JJ, Gu W, Shirayama M, Conte D Jr, Yates JR 3rd, Mello CC. |
| タイトル | Argonautes promote male fertility and provide a paternal memory of germline gene expression in C. elegans. |
| ジャーナル | Cell |
| Abstract |
During each life cycle, germ cells preserve and pass on both genetic and epigenetic information. In C. elegans, the ALG-3/4 Argonaute proteins are expressed during male gametogenesis and promote male fertility. Here, we show that the CSR-1 Argonaute functions with ALG-3/4 to positively regulate target genes required for spermiogenesis. Our findings suggest that ALG-3/4 functions during spermatogenesis to amplify a small RNA signal that represents an epigenetic memory of male-specific gene expression. CSR-1, which is abundant in mature sperm, appears to transmit this memory to offspring. Surprisingly, in addition to small RNAs targeting male-specific genes, we show that males also harbor an extensive repertoire of CSR-1 small RNAs targeting oogenesis-specific mRNAs. Together, these findings suggest that C. elegans sperm transmit not only the genome but also epigenetic binary signals in the form of Argonaute/small RNA complexes that constitute a memory of gene expression in preceding generations. |
| 巻・号 | 155(7) |
| ページ | 1532-44 |
| 公開日 | 2013-12-19 |
| DOI | 10.1016/j.cell.2013.11.032 |
| PII | S0092-8674(13)01483-9 |
| PMID | 24360276 |
| PMC | PMC3924572 |
| MeSH | Animals Caenorhabditis elegans / genetics Caenorhabditis elegans / metabolism* Caenorhabditis elegans Proteins / metabolism* Epigenesis, Genetic* Female Male RNA, Small Untranslated / metabolism RNA-Binding Proteins / metabolism* Signal Transduction Spermatogenesis* Spermatozoa Transcription, Genetic |
| IF | 38.637 |
| 引用数 | 76 |
| WOS 分野 | BIOCHEMISTRY & MOLECULAR BIOLOGY CELL BIOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 23 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 線虫 | tm1155 tm1361 tm892 |