| RRC ID |
30651
|
| Author |
Maures TJ, Booth LN, Benayoun BA, Izrayelit Y, Schroeder FC, Brunet A.
|
| Title |
Males shorten the life span of C. elegans hermaphrodites via secreted compounds.
|
| Journal |
Science
|
| Abstract |
How an individual's longevity is affected by the opposite sex is still largely unclear. In the nematode Caenorhabditis elegans, the presence of males accelerated aging and shortened the life span of individuals of the opposite sex (hermaphrodites), including long-lived or sterile hermaphrodites. The male-induced demise could occur without mating and required only exposure of hermaphrodites to medium in which males were once present. Such communication through pheromones or other diffusible substances points to a nonindividual autonomous mode of aging regulation. The male-induced demise also occurred in other species of nematodes, suggesting an evolutionary conserved process whereby males may induce the disposal of the opposite sex to save resources for the next generation or to prevent competition from other males.
|
| Volume |
343(6170)
|
| Pages |
541-4
|
| Published |
2014-1-31
|
| DOI |
10.1126/science.1244160
|
| PII |
science.1244160
|
| PMID |
24292626
|
| PMC |
PMC4126796
|
| MeSH |
Animals
Biological Evolution
Caenorhabditis elegans / drug effects
Caenorhabditis elegans / genetics
Caenorhabditis elegans / physiology*
Caenorhabditis elegans Proteins / genetics
Carrier Proteins / genetics
Culture Media, Conditioned / metabolism
Culture Media, Conditioned / pharmacology
Female
Gene Expression Regulation
Genes, Helminth / genetics
Longevity / drug effects
Longevity / genetics
Longevity / physiology*
Male
Peptide Hormones / genetics
RNA Interference
|
| IF |
41.846
|
| Times Cited |
84
|
|
WOS Category
|
MULTIDISCIPLINARY SCIENCES
|
| Resource |
| C.elegans |
tm1053 |
