RRC ID 30667
著者 Sun B, Looi LS, Guo S, He Z, Gan ES, Huang J, Xu Y, Wee WY, Ito T.
タイトル Timing mechanism dependent on cell division is invoked by Polycomb eviction in plant stem cells.
ジャーナル Science
Abstract Plant floral stem cells divide a limited number of times before they stop and terminally differentiate, but the mechanisms that control this timing remain unclear. The precise temporal induction of the Arabidopsis zinc finger repressor KNUCKLES (KNU) is essential for the coordinated growth and differentiation of floral stem cells. We identify an epigenetic mechanism in which the floral homeotic protein AGAMOUS (AG) induces KNU at ~2 days of delay. AG binding sites colocalize with a Polycomb response element in the KNU upstream region. AG binding to the KNU promoter causes the eviction of the Polycomb group proteins from the locus, leading to cell division-dependent induction. These analyses demonstrate that floral stem cells measure developmental timing by a division-dependent epigenetic timer triggered by Polycomb eviction.
巻・号 343(6170)
ページ 1248559
公開日 2014-1-31
DOI 10.1126/science.1248559
PII 343/6170/1248559
PMID 24482483
MeSH AGAMOUS Protein, Arabidopsis / genetics AGAMOUS Protein, Arabidopsis / metabolism* Arabidopsis / cytology Arabidopsis / genetics Arabidopsis / growth & development* Arabidopsis Proteins / genetics Arabidopsis Proteins / metabolism* Base Sequence Carrier Proteins / genetics Carrier Proteins / metabolism* Cell Division / genetics Cell Division / physiology* Epigenesis, Genetic Flowers / cytology Flowers / genetics Flowers / growth & development* Gene Expression Regulation, Plant Meristem / cytology* Molecular Sequence Data Plants, Genetically Modified / cytology Plants, Genetically Modified / growth & development Polycomb-Group Proteins / genetics Polycomb-Group Proteins / metabolism* Promoter Regions, Genetic Stem Cells / cytology* Time Factors Trans-Activators / genetics Trans-Activators / metabolism
IF 41.846
引用数 104
WOS 分野 BIOCHEMISTRY & MOLECULAR BIOLOGY
リソース情報
シロイヌナズナ / 植物培養細胞・遺伝子 rpc00008